Sökning: "gluconoylation"

Hittade 2 uppsatser innehållade ordet gluconoylation.

  1. 1. Process development for the production of a therapeutic Affibody® Molecule

    Master-uppsats, Institutionen för biologisk grundutbildning

    Författare :Belinda Fridman; [2014]
    Nyckelord :Affibody® Molecule; HER3; EGFR; HER2; cancer therapy; process development; DOE; multivariate data analysis; E. coli; ABD; plasma half-life; thermolysis; fed-batch; gluconoylation; BL21 DE3 ; T7 expression system;

    Sammanfattning : Recently HER3, member of the epidermal growth factor receptor family (EGFR), has been found to play a crucial role in the development of resistance towards inhibitors that are given to patients with HER1- and HER2-driven cancers. As HER3 is up-regulated or over-activated in several types of human cancers, it is of outmost importance that new innovative drugs target its oncologic activity. LÄS MER

  3. 2. High-throughput Fed-batch Production of Affibody® molecules in a novel Multi-fermentor system

    Uppsats för yrkesexamina på grundnivå, Institutionen för fysik, kemi och biologi

    Författare :Johan Larsson; [2005]
    Nyckelord :Escherichia coli; fed-batch; Affibody® molecules; phosphogluconoylation;

    Sammanfattning : The present Master thesis describes the development and optimization of a fed-batch process for production of recombinant proteins in Escherichia coli BL21(DE3) in a multi-fermentor system. The system consists of six 1-liter fermentors, capable of producing 500-1500 μg/mL with present protocol. LÄS MER