Sökning: "hematopoietic stem cell"

Visar resultat 1 - 5 av 14 uppsatser innehållade orden hematopoietic stem cell.

  1. 1. Method development of magnetic cell isolation and DNA extraction of small cell populations from Ficoll-separated hematopoietic cells

    Kandidat-uppsats, Uppsala universitet/Institutionen för medicinsk cellbiologi

    Författare :Dominika Debowska; [2023]
    Nyckelord :Clonal haematopoiesis of indeterminate potential CHIP ; hematopoietic stem cell; automated cell separation; silica-membrane-based nucleic acid purification.;

    Sammanfattning : Clonal haematopoiesis of indeterminate potential, or CHIP are a family of mutations present in the general population. CHIP-mutations are prevalent in the haematopoietic stem cells and in the more mature cell populations, T-lymphocytes, B-lymphocytes and myeloid cells (CD3+, CD19+ and CD33+ cells) in blood. LÄS MER

  3. 2. Patienter med hematologisk cancer och deras upplevelser av att genomgå stamcellstransplantation

    Kandidat-uppsats, Uppsala universitet/Institutionen för folkhälso- och vårdvetenskap

    Författare :Maria Lindeberg; Evelina Gommel; [2023]
    Nyckelord :Experiences; patient; protective isolation; stem cell transplantation; Patient; skyddsisolering; stamcellstransplantation; upplevelser;

    Sammanfattning : Introduktion: Patienter med hematologisk cancer kan genomgå en stamcellstransplantation som behandling för att få nya blodbildande stamceller. Målet med transplantationen samt cytostatikabehandling är överlevnad för patienten och att bota malignitet. LÄS MER

  4. 3. Hypoxia and hematopoietic stem cell control with the substance Adaptaquin : An evaluation of hematopoietic stem cell’s proliferation and differentiation in artificially induced hypoxia

    Kandidat-uppsats, Malmö universitet/Institutionen för biomedicinsk vetenskap (BMV)

    Författare :Jens Christiansen; [2023]
    Nyckelord :Adaptaquin; Flow cytometry; Hematopoietic stem cells; Hypoxia; Hypoxia inducible factor; Prolyl hydroxylase; Adaptaquin; Flödescytometri; Hematopoetiska stamceller; Hypoxi; Hypoxi inducerande faktor; Prolylhydroxylas;

    Sammanfattning : Hematopoietic stem cells (HSCs) have historically been difficult to maintain ex vivo with many attempts to culture them in vitro by mimicking their natural biological environment. Providing a hypoxic environment is one way to achieve this goal and can be performed by using hypoxia stimulating compounds that inhibits the degradation of HIF1a which plays an important role in regulating hypoxia. LÄS MER

  5. 4. Validation of a Next Generation Sequencing based method for chimerism analysis in clinical practice

    Kandidat-uppsats, Uppsala universitet/Institutionen för medicinsk cellbiologi

    Författare :Maria Högberg; [2022]
    Nyckelord :Devyser chimerism; fragment analysis; hematopoietic stem cell transplantation; short tandem repeats; indels;

    Sammanfattning : Hematopoietic stem cell transplantation (HSCT) is used to treat patient with hematological diseases such as leukemia and genetic conditions such as sickle cell anemia. After HSCT the patients are supervised for signs of relapse of disease or rejection of transplanted cells. This is done by using chimerism analysis. LÄS MER

  7. 5. Lipidomic profiling of multiple sclerosis patients undergoing autologous hematopoietic stem cell transplantation

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Aina Vaivade; [2021]
    Nyckelord :Lipidomcis; mass spectrometry; polarity switching; AHSCT; autologous hematopoietic stem cell transplantation; multiple sclerosis;

    Sammanfattning : Background: Multiple sclerosis (MS) is a neurological, autoimmune disease which mainly affects people in the age of 20 to 40. The disease course is unpredictable affecting each patient differently, leading to progressiveand irreversible degradation of the central nervous system. LÄS MER