Sökning: "parameter determination"

Visar resultat 1 - 5 av 58 uppsatser innehållade orden parameter determination.

  1. 1. Translation of pharmacometric models from NONMEM to nlmixr2 and RxODE2

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Johan Borg; [2023]
    Nyckelord :pharmacy; pharmacokinetics; pharmacodynamics; nlmixr; nlmixr2; rxode; rxode2; conversion; translation; NONMEM; PK; PD; PK PD; model; modeling; modelling;

    Sammanfattning : The gold standard for pharmacometrics modeling, along with its modeling format, is currently NONMEM. In order to use other software, there is often a manual step of converting a model from one format to another, which is both time-consuming and causes manual errors. LÄS MER

  3. 2. Optimization of two high-performance size-exclusion chromatography methods with diode-array detection for protein quantification and purity assessment

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Camilla Lane; [2023]
    Nyckelord :Method qualification; Protein concentration; Protein Purity; High Performance Size exclusion chromatography; Quality control; Analytical chemistry; Biology and Life Sciences;

    Sammanfattning : Background: There is a need to develop methods of determining concentration and purity for two new affinity ligands, protein T and protein H, in order to ensure the quality of an industrial production of said proteins. Aims: To develop a High Performance Size Exclusion Chromatography, HPSEC, method to determine concentration and purity of protein T and to improve an existing HPSEC method for concentration and purity determination of protein H that show selectivity, display linearity between peak area and injection amount and give repeatable results. LÄS MER

  4. 3. Content determination of explosive precursors and narcotic salts using 35Cl-nuclear magnetic resonance

    Uppsats för yrkesexamina på grundnivå, Örebro universitet/Institutionen för naturvetenskap och teknik

    Författare :Sandra Bergqvist; [2023]
    Nyckelord :Nuclear magnetic resonance NMR ; explosive precursors; narcotic salts; method validation.;

    Sammanfattning : Explosive precursors and narcotic salts are chemicals contributing to an undesirabledevelopment of the Swedish society, both in terms of criminal activities and harm to the environment. Reducing the illegal use of these chemicals is important in the work towards a safer society. LÄS MER

  5. 4. Feasibility of quantitative 99mTc-DPD scintigraphy SPECT/CT for assessing the burden of ATTR cardiac amyloidosis

    Master-uppsats, Umeå universitet/Radiofysik

    Författare :Sajad Kadhim Khalaf; [2023]
    Nyckelord :QSPECT; Amyloidosis; ATTR; LVMI; Recovery Coefficient; SUV; Calibration;

    Sammanfattning : Background: Amyloid transthyretin (ATTR) cardiomyopathy is caused by the deposition of misfolded proteins, known as amyloid fibrils, in the myocardium. Quantitative Single Photon Emission Computed Tomography (QSPECT) utilizing 99mTc-DPD scintigraphy has the potential to assess ATTR-suspected cardiac amyloidosis (CA). LÄS MER

  7. 5. Spectroscopic determination of stellar parameters to constrain atomic diffusion in the old open cluster M67

    Kandidat-uppsats, Uppsala universitet/Institutionen för fysik och astronomi

    Författare :Fabian Lundell; [2022]
    Nyckelord :;

    Sammanfattning : In an attempt to check published results on diffusion effects in M67 a non-LTE analysis is made on 28 high resolution FLAMES-UVES spectra of dwarfs and sub-giants around the turnoff point, where core hydrogen fusion halts. This analysis utilizes the software-suites LOTUS and iSpec to determine stellar parameters from equivalent-width measurements. LÄS MER