Sökning: "pharmaceutical excipients"

Visar resultat 1 - 5 av 13 uppsatser innehållade orden pharmaceutical excipients.

  1. 1. Comparison of properties on Orally Disintegrating Tablets (ODTs) produced by direct compression or fluid bed granulation

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Julia Ahlbom; [2023]
    Nyckelord :Orally disintegrating tablet; fluid bed granulation; disintegration time; pharmaceutical technology; Technology and Engineering;

    Sammanfattning : Orally disintegrating tablets (ODTs) is a popular drug delivery system as they dissolve in the mouth, usually within seconds which enables easy medication for patients with problem swallowing. In this thesis properties of ODTs were compared when produced with direct compression of the excipients or the excipients were pretreated to form granules in a fluid bed granulator prior to tableting. LÄS MER

  2. 2. Methods to study device induced aggregation of proteins

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Marie Therese von Wowern; [2023]
    Nyckelord :protein formulation; protein aggregation; insulin; silicone oil; syringe; shear stress; subvisible particle; size exclusion chromatography; flow imaging microscopy; pharmaceutical technology; Technology and Engineering;

    Sammanfattning : This work developed a method for the investigation of how medical devices, such as syringes and needles, affect the formation of subvisible particles in a protein drug without excipients. Protein-based pharmaceuticals are well known to be sensitive to different kinds of stress, and exposure to stress during the use of this device is unavoidable. LÄS MER

  3. 3. The effect of lactose fines, magnesium stearate, choice of mixer and mixing process on the performance of adhesive mixtures for inhalation

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Gabriela Ponce Aparicio; [2023]
    Nyckelord :High shear mixing; low shear mixing; lactose fines; coating agent; budesonide; mixing energy; dry powder inhaler; carrier-based formulations; mixing time; adhesive mixtures; pharmaceutical technology; Technology and Engineering;

    Sammanfattning : Dry powder inhaler (DPI) formulation is a major area of interest since they are employed by the healthcare system to treat relevant chronic diseases like asthma. Previous research has established that the manufacturing process and formulation composition are key for the active pharmaceutical ingredient to reach the lungs and achieve therapeutic effects. LÄS MER

  4. 4. The Link between Particle Hardness and Plastic Stiffness in Pharmaceutical Excipients : Exploring the Impact of Mechanical Properties on Tablet Strength and Stiffness

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Alexandra Katumba; [2023]
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  5. 5. Effects of pharmaceutical excipients on the chemical stability of therapeutic proteins in a parenteral formulation

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Emmanuel Gulangayan Deniola; [2022]
    Nyckelord :Chemical stability; protein degradation; GA-Z; somatropin; pharmaceutical excipients; liquid chromatography; pharmaceutical technology; Chemistry;

    Sammanfattning : Proteins and peptides are widely used for the prevention, management, and cure of various illnesses. This vast therapeutic potential represents a significant portion of the pharmaceutical industry in the form of vaccines, antibodies, enzymes, and other protein-based therapeutics. LÄS MER