Sökning: "Antibiotic resistance mechanism"

Visar resultat 1 - 5 av 13 uppsatser innehållade orden Antibiotic resistance mechanism.

  1. 1. Measuring bacterial metabolism and antibioticsusceptibility : using silicon nanowire field-effect transistor.

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Fasta tillståndets elektronik

    Författare :George Alhoush; [2024]
    Nyckelord :Silicon nanowire field effective transistor; SiNWFET; Ion-selective filed effect transistor; ISFET; Antibiotic susceptibility test; AST; Measuring bacterial metabolism using microchip;

    Sammanfattning : Antimicrobial resistance is considered by many prominent researcher and scientist as a profound global health crisis that us humans must face in the next decade. It is threatening the effectiveness of these once-reliable weapons against bacterial infections and leaving us susceptible to pathogenic agents. LÄS MER

  3. 2. An Overview Of The Antibiotic Resistance Mechanisms Of Common Gram Positive And Gram Negative Multidrug Resistant Bacteria

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för biologi och miljö (BOM)

    Författare :Elisabeth Tammi; [2023]
    Nyckelord :Antibiotic resistance mechanism; gram negative bacteria; gram positive bacteria;

    Sammanfattning : Antibiotic resistance in multidrug resistant bacteria cause high mortality rates worldwide, where there has been over 1,000,000 deaths reported as of the year 2019. Antibiotics were thought to be the cure for fighting infectious diseases and preventing further spreading of infection. LÄS MER

  4. 3. The Binding Mechanism of Carbapenems in the Class A beta-lactamase IMI-1 : A Molecular Dynamics Study of Ligand Stability

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Biokemi

    Författare :Isabell Lindahl; [2022]
    Nyckelord :antibiotic resistance; IMI-1; betalactamase; Carbapenemase; free energy; LIE; linear interaction energy; β-lactamase; meropenem; biapenem; imipenem; active site;

    Sammanfattning : Antibiotic resistance is a global and accelerating matter. Over time, the bacteria have evolved several defense mechanisms against the antibiotics. One of the defense mechanisms is that the bacteria can produce enzymes with the ability to hydrolyze the characteristic b-lactam ring of the antibiotics. These enzymes are called b-lactamases. LÄS MER

  5. 4. Drug Design of β-Lactamase Inhibitors of the DBO-scaffold against OXA-48 : A Molecular Dynamics Study of Ligand Stability in the Michaelis Complex

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Läkemedelsdesign och läkemedelsutveckling

    Författare :Linda Liljeholm; [2022]
    Nyckelord :OXA-48; β-lactamase; DBO inhibitors; diazabicyclooctane; avibactam; relebactam; β-lactamase inhibitor; BLI; molecular dynamics; LIE; Linear Interaction Energy; antibiotic resistance; drug design;

    Sammanfattning : The emergence of β-lactamase-mediated antibiotic resistance is one of the biggest threats in modern times. Combined with the discovery void of new forms of antibiotics, this sets the course toward a future where the efficacy of present-day health care will be jeopardized. LÄS MER

  7. 5. Biofilm formation and antibiotic resistance in klebsiella pneumoniae: a meta-analysis study

    Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Afzal Mohammed; [2021]
    Nyckelord :Biofilm; Antibiotic Resistance; Antimicrobial Resistance; K. Pneumonia;

    Sammanfattning : The study explored the prevalence of biofilm formers and its association with multidrug resistance in Klebsiella Pneumonia, a gram-negative bacterium that has high propensity to form antibiotic resistant strains and forms biofilms. Biofilms are complex microbial community with attributes that vary from planktonic cells. LÄS MER