Sökning: "CRISPR-Cas systems"

Hittade 3 uppsatser innehållade orden CRISPR-Cas systems.

  1. 1. Preimplantation genetic diagnosis and therapy in humans- Opportunities and risks

    Master-uppsats, Örebro universitet/Institutionen för medicinska vetenskaper

    Författare :Rickard Hedberg; [2020]
    Nyckelord :Preimplantation genetic diagnosis; CRISPR-Cas systems; gene editing; germline; genome; ethics; autonomy; beneficence; risks.;

    Sammanfattning : IntroductionPreimplantation Genetic Diagnosis (PGD) was developed in the 1990s and has been used since to diagnose and discard embryos with genetic conditions or chromosomal abnormalities. CRISPR-Cas9 was discovered in 2012 and has been used in research, but has not become clinical practice on humans yet. LÄS MER

  3. 2. A canonical correlation analysis- based approach to identify causal genes in atherosclerosis

    Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Crisencia Sizyoogno; [2018]
    Nyckelord :Canonical correlation analysis; Atherosclerosis; bioinformatics; CRISPR_Cas9; Phenotypes; Genotypes; GWAS; zebrafish; Cardiovascular and metabolic disease;

    Sammanfattning : Genome-wide associations studies (GWASs) have identified hundreds of loci that are strongly associated with coronary artery disease and its risk factors. However, the causal variants and genes remain unknown for the vast majority of the identified loci. LÄS MER

  4. 3. A platform for Chinese hamster ovary (CHO) cell genome engineering

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Jiten Doshi; [2016]
    Nyckelord :Chinese hamster; lentivirus; RMCE;

    Sammanfattning : The production of therapeutic recombinant proteins in heterologous systems has gained significance since the last decade. For recombinant proteins that require post-translational modifications (PTMs), mammalian systems are preferred. Chinese hamster ovary (CHO) cells are the mammalian cells of choice for production of recombinant proteins. LÄS MER