Sökning: "Limit of detection"

Visar resultat 1 - 5 av 197 uppsatser innehållade orden Limit of detection.

  1. 1. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemi

    Författare :Maryam Dost; [2024]
    Nyckelord :Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Sammanfattning : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. LÄS MER

  3. 2. A novel assay for the detection of Hepatitis C virus in blood plasma, using padlock probes and rolling circle amplification

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Andréa Karlsson; [2023]
    Nyckelord :;

    Sammanfattning : Hepatitis C viral infection is a globally widespread blood-borne disease affecting the liver, causing cirrhosis and hepatocellular carcinoma. This type of liver cancer is mainly caused by chronic Hepatitis C and Hepatitis B. Specific detection with the following correct treatment is crucial to reduce the overall burden of the disease. LÄS MER

  4. 3. Är mjölkprover en alternativ provtagningsmetod för diagnostik av lentivirus hos små idisslare?

    Master-uppsats, SLU/Dept. of Clinical Sciences

    Författare :Elin Fogelberg; [2023]
    Nyckelord :maedi-visna; kaprin artrit encefalit; SRLV; serum; mjölk; pool; frysning; kontrollprogram; ELISA;

    Sammanfattning : Lentivirus hos små idisslare (engelska: small ruminant lentivirus; SRLV) innefattar två olika virus: visna-maedivirus (VMV) och kaprin artrit encefalitvirus (CAEV). Dessa två virus orsakar kroniska infektioner hos små idisslare som slutligen leder till döden. LÄS MER

  5. 4. Development of specific host cell protein assays

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Anna Ivert Nordén; [2023]
    Nyckelord :Gyrolab; Immunoassay; HCP;

    Sammanfattning : The manufacturing and the development of biotherapeutic drugs involves the expression of biotherapeutic proteins in a host cell expression system followed by a purification process. Bioanalytical methods to measure impurities such as host cell proteins (HCPs) are needed to obtain a robust process and a safe drug according to regulatory requirements. LÄS MER

  7. 5. Increased system sensitivity using fluorescent based immunoassays on the Gyrolab® platform

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Gabriel Lisra; [2023]
    Nyckelord :Gyrolab; fluorescence; sensitivity; immunoassays;

    Sammanfattning : Immunoassays have become an essential tool in several fields of bioanalytics with tremendous advances in sensitivity and formats seen through the last three decades. Many diseases are today diagnosed solely based on biomarker concentrations evaluated through immunoassays. LÄS MER