Sökning: "ZIC-HILIC"

Hittade 4 uppsatser innehållade ordet ZIC-HILIC.

  1. 1. Kromatografi av polära läkemedel och metaboliter med HILIC-teknik

    Kandidat-uppsats, Institutionen för fysik, kemi och biologi; Tekniska högskolan

    Författare :Cassandra Jaque; Anders Johansson; [2013]
    Nyckelord :HILIC; XBridge Amide; ZIC-HILIC; ZIC-pHILIC;

    Sammanfattning : The purpose of this project was to investigate if retention of polar compounds that are given to treat tuberculosis, diabetes, inflammatory bowel disease and childhood leukemia could be obtained with HILIC separation. By varying different parameters for different types of columns the compounds were analyzed with the aim of finding guidelines for future method optimizations. LÄS MER

  3. 2. Determination of Cisplatin using Hydrophilic Interaction Liquid Chromatography (HILIC) Coupled with Inductively Coupled Plasma Mass Spectrometry (ICP-MS): A Study on Cisplatin’s Retention Mechanisms in HILIC and Uptake and Intracellular Decay Kinetics in in-vitro Grown Cells

    Master-uppsats, Kemiska institutionen

    Författare :Tinh Le; [2012]
    Nyckelord :;

    Sammanfattning : Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is widely used for the treatment of several solid tumors. The antitumor property of cisplatin is generally proved that the covalent binding of cisplatin to DNA distorts the DNA structure, which leads to the death of the cancer cells. LÄS MER

  4. 3. Intracellular half-life of cisplatin in malignant cells : A kinetic study of the decline rate of intracellular cisplatin concentration in in-vitro grown cells determined by LC-ICP-MS following exposure to clinically relevant cisplatin doses

    Master-uppsats, Kemiska institutionen

    Författare :Liem Nguyen Van; [2011]
    Nyckelord :;

    Sammanfattning : Cisplatin is a common cancer therapy substance used against several types of malignant tumors and often shows great efficiency. The most important tumour killing mechanism is believed to be formation of Pt-DNA adducts. It is however a common phenomenon that tumors develop resistance causing inefficient treatment. LÄS MER

  5. 4. Simultan kvantifiering av metylmalon­syra och total homocystein : En kombinationsmetod baserad på hydrofil interaktion vätskekromatografi och elektrospray jonisations­masspektrometri

    Uppsats för yrkesexamina på grundnivå, Biomedicinsk laboratorievetenskap

    Författare :Sindy Palm; [2011]
    Nyckelord :Hydrophilic Interaction Liquid Chromatography; SeQuant™ ZIC®-HILIC; masspektrometri; Metylmalonsyra; Homocystein; B-vitaminbrist; TCEP;

    Sammanfattning : .... LÄS MER