Sökning: "caspase"

Visar resultat 1 - 5 av 10 uppsatser innehållade ordet caspase.

  1. 1. Upregulation of CLIC1 gene in THP1 cells stimulated by lipopolysaccharides

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Karldiony Roskvist; [2021]
    Nyckelord :;

    Sammanfattning : The NLRP3 inflammasome is a multiprotein complex that controls caspase-1 activation and the development of the pro-inflammatory cytokines IL-1 and IL-18, as well as pyroptosis. The NLRP3 inflammasome in murine macrophages is normally triggered by pathogen-associated molecular patterns as well as a variety of structurally unrelated stimuli. LÄS MER

  3. 2. Utilizing cytotoxic lymphocytes for indirect shock-and-kill strategy in HIV-1 treatment

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Joana FIlipa Furtado Milão; [2021]
    Nyckelord :HIV-1; Shock-and-kill strategy; NK cells; latency reservoir; HIV-1 treatment;

    Sammanfattning : Despite the existence of a treatment, there is still not a cure for HIV-1 infection and there arearound 700 000 deaths per year from AIDS-related diseases. A major barrier for a cure is theestablishment of latent reservoirs that are impossible to distinguish from healthy cells and thuscan escape the immune system. LÄS MER

  4. 3. Protein-protein interactions with and within the NLRP3 inflammasome : Evidence from STRING and literature studies

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Ralph Monte; [2020]
    Nyckelord :;

    Sammanfattning : Inflammasomes are multiprotein complexes that play a role in the innate immune system. One inflammasome is the NLRP3 inflammasome, which can be activated and primed by different stimuli that bind to pattern recognition receptors (PRRs). LÄS MER

  5. 4. Inflammasome : Investigating the effect of NEK7 in the activation of the NLRP3 Inflammasome

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Cosmas Adindu Uzowuru; [2020]
    Nyckelord :NLRP3 inflammasome; NEK7 protein; THP-1; Prime; activate; differentiate; stimulate; cytokines; Interleukin-1 Beta; Interleukin-18;

    Sammanfattning : Inflammation is a biological defence mechanism applied by living organisms against foreign invaders. In the response to DAMPs and PAMPs, organisms use inflammatory multi-protein complexes to fight the attackers. The most studied inflammasome proteins are NLRP3, ASC and Caspase-1. LÄS MER

  7. 5. The effects of NOX2 and NOX4 inhibitors on panc-1 cell viability

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för hälsovetenskaper

    Författare :Karl-Hermann Sielinou Kamgang; [2020]
    Nyckelord :;

    Sammanfattning : Pancreatic cancer is a leading cause of cancer related deaths worldwide and has a low survival rate 1 year after diagnosis. It is therfore important to identify new biomarkers and treatments to improve disease outcome. This experiment investigated the effects of different NOX2 and NOX4 inhibitors on Panc-1 cell lines. LÄS MER