Sökning: "cell cycle checkpoint"

Visar resultat 1 - 5 av 6 uppsatser innehållade orden cell cycle checkpoint.

  1. 1. Mapping the Expression of Cyclin Dependent Kinase Inhibitors in High-Risk Neuroblastoma Cell Lines : Dynamics on Cell-Fate Decisions on Proliferation/Cell Cycle Arrest

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Ximena López Lorenzo; [2020]
    Nyckelord :Neuroblastoma; NMYC; p53; cell cycle checkpoint; inhibition; regrowth; p21; p27; SKP2; CHK1 2; Neuroblastoma; NMYC; p53; cellcykel checkpoint; hämning; återväxt; p21; p27; SKP2; CHK1 2;

    Sammanfattning : Poor prognosis for high-risk neuroblastoma patients makes it necessary to find novel treatmentstrategies. This work aims to understand the cell cycle behavior of various high-riskneuroblastoma cell lines following chemotherapy treatment. LÄS MER

  3. 2. Nascent RNA sequencing of unperturbed newly divided cells

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Luke Parks; [2017]
    Nyckelord :cell cycle; cell synchronization; nascent RNA sequencing;

    Sammanfattning : Establishing a definitive cell cycle progression has been one of the fundamental aims of cellular biology. Its importance lies in gaining insight into the basic processes of life as well as the functions of mutant cell cycle pathways in promoting cancer by replication deficiencies and loss of checkpoint control. LÄS MER

  4. 3. Elucidation of the role of the MICOS complex in signal transduction from mitocondrial DNA nucleoids

    Master-uppsats, Lunds universitet/Tillämpad biokemi

    Författare :Michael Hellman; [2015]
    Nyckelord :tillämpad biokemi; applied biochemistry; Chemistry; Technology and Engineering; Biology and Life Sciences;

    Sammanfattning : The MICOS complex protein MicF has recently been identified to play a vital role in the mitochondrial DNA inheritance checkpoint, a control system that halts cell cycle progression in cells lacking mitochondrial DNA (mtDNA). We show in this report that another member of the complex, MicA, also plays an important role in the mtDNA inheritance checkpoint as its deletion led to cell cycle progression in cells lacking mtDNA (Rho0 cells). LÄS MER

  5. 4. The control of the cell cycle with particular emphasis on the G1/S transition

    Kandidat-uppsats, SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Författare :Erika Andersson; [2014]
    Nyckelord :G1 S; cellcykel; restriktionspunkt; tumör; cyklin; cdk; cell cycle; restriction point; checkpoint; tumour; cyclin;

    Sammanfattning : Tumour development occurs to a large extent because of dysregulation of the cell cycle. Of particular importance are defects occurring in the G1 phase. The reason why G1 is critical is because of the influence of several signals (external signals as well as cyclins and cdks) on this stage. The G1 phase can be divided into two parts, G1pm and G1ps. LÄS MER

  7. 5. Genetic analysis of the fission yeast

    Master-uppsats, Lunds universitet/Examensarbeten i molekylärbiologi

    Författare :Nima Borhan Fakouri; [2012]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : ABSTRACT Ribonucleotide reductase (RNR) catalyzes the rate‐limiting step of dNTP production. The availability of finely tuned dNTP pools is very important to maintain genome stability during DNA synthesis for replication and repair. Therefore the activity of RNR is tightly regulated via various mechanisms. LÄS MER