Sökning: "de novo"

Visar resultat 1 - 5 av 61 uppsatser innehållade orden de novo.

  1. 1. Design and Evaluation of Peptide Binders : In silico evaluation and comparison of generative AI for de novo peptide binder design

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Beräkningsbiologi och bioinformatik

    Författare :Linde Brokmar; [2023]
    Nyckelord :Protein design; de novo design; protein engineering; generative ai; machine learning; peptide binders; AF2; EvoBind; RFdiffusion; ProteinMPNN;

    Sammanfattning : Peptide binders are short proteins that bind to larger proteins. Due to peptide binders having high specificity and being cheap to synthesize, they are a prime candidate for drug design. Creating new proteins in silico can be divided into three steps: protein backbone generation, sequence design, and computational filtering. LÄS MER

  3. 2. EVALUATING TRANSCRIPTOME ASSEMBLY POTENTIAL BY DIFFERENT DE NOVO SEQUENCE ASSEMBLER TYPES

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Luan Gardenalli; [2023]
    Nyckelord :;

    Sammanfattning : With the rise of NGS technologies, the transcriptomes of non-model organisms can be reconstructed even with the absence of a reference genome, using de novo assembly tools. There is a wide range of de novo assembly tools frequently being developed, however, there is a still a knowledge gap about the different effects and efficiency of different de novo assembly software types for RNA-seq assembly. LÄS MER

  4. 3. Robust Non-Linear State Estimation for Underwater Acoustic Localization : Expanding on Gaussian Mixture Methods

    Master-uppsats, KTH/Skolan för elektroteknik och datavetenskap (EECS)

    Författare :Diogo Antunes; [2023]
    Nyckelord :Robust state estimation; Underwater localization; Target tracking; Gaussian mixture; AUV; Estimação robusta de estado; Localização subaquática; Rastreamento de alvos; Mistura Gaussiana; AUV; Robust tillståndsuppskattning; Undervattenslokalisering; Målspårning; Gaussisk blandning; AUV;

    Sammanfattning : Robust state estimation solutions must deal with faulty measurements, called outliers, and unknown data associations, which lead to multiple feasible hypotheses. Take, for instance, the scenario of tracking two indistinguishable targets based on position measurements, where each measurement could refer to either of the targets or even be a faulty reading. LÄS MER

  5. 4. Empagliflozins effekter vid behandling av akut hjärtsvikt

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Suchada Sathornkit; [2023]
    Nyckelord :SGLT2 inhibitors; Empagliflozin; Acute heart failure; Acute decompensated heart failure; Decongestion therapy; Diuretics;

    Sammanfattning : Akut hjärtsvikt definieras som en debut eller försämring av hjärtsvikt. Hjärtsvikt är ett allvarligt tillstånd där hjärtat inte upprätthåller adekvat hjärtminutvolym för att möta kroppens metaboliska behov vilket leder till trötthet och försämrad livskvalitet. LÄS MER

  7. 5. From pastures to plates: The thorny path to achieving deforestation-free cattle from Brazil to European consumers

    Master-uppsats, Lunds universitet/LUCSUS

    Författare :Matias Vaccarezza Sevilla; Gino Pedreira Lucchese; [2023]
    Nyckelord :EU Regulation; Deforestation-Free Commodities; Cattle Supply Chain; Sustainability Science; Foreign Accountability; Social Sciences;

    Sammanfattning : Para combater o desmatamento global, a UE promulgou um novo regulamento sobre produtos livres de desmatamento em 2023. O regulamento tem como objetivo eliminar o desmatamento ligado à produção de commodities específicas, exigindo rastreabilidade completa e diligência das empresas importadoras da UE. LÄS MER