Sökning: "Kinases"

Visar resultat 1 - 5 av 29 uppsatser innehållade ordet Kinases.

  1. 1. Regulatory Driven Clustering of Single-Cell Data; Clustering of single-cell RNA sequencing from glioblastoma with a novel mathematical method

    Master-uppsats, Göteborgs universitet/Institutionen för matematiska vetenskaper

    Författare :Kári Kristjánsson; [2023-08-08]
    Nyckelord :;

    Sammanfattning : Cancer is a leading cause of death worldwide. Single-cell RNA sequencing has arisen as an important method to explore the gene expression of biological cells, including cancer cells. In this study, we deployed a computational algorithm known as ScRegClust to dissect single-cell RNA-sequencing (scRNA-seq) data from brain tumors. LÄS MER

  3. 2. Effects of phosphorylation on the ADP-ribosylation activity of PARP16

    Kandidat-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Virginia Martín Cristóbal; [2023]
    Nyckelord :ADP-ribosylation; Kinases; PARP16; Phosphorylation; UPR biochemistry; Biochemistry; Chemistry;

    Sammanfattning : PARP16/ARTD15 is an intracellular mono-ADP-ribosyltransferase that catalyzes auto- and heteromodification by transfer of a single ADP-ribose moiety. It belongs to the ADP-ribosyltransferase (ART) superfamily. LÄS MER

  4. 3. Ligand-stimulated cleavage of PDGFR-beta

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Agni Karolina Tsiatsiou; [2023]
    Nyckelord :;

    Sammanfattning : Platelet-derived growth factor receptors (α and β) are included in the family of receptor tyrosine kinases (RTKs). The dimeric PDGF ligands bind to the PDGF receptors and this results in receptor dimerization, autophosphorylation, and thus activation. The autophosphorylated receptor dimer activates numerous signaling pathways. LÄS MER

  5. 4. Bioinformatics analysis on the drug design supporting systems

    Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Emilia Guszpit; [2023]
    Nyckelord :;

    Sammanfattning : This research project investigates the interactions of staurosporine, a potent kinase inhibitor, with 11 ligands, highlighting its role in drug design and bioinformatics. Focusing on the selectivity and promiscuity of staurosporine in binding to protein kinases, the study employs the MANORAA database for data extraction. LÄS MER

  7. 5. Alternativ Splicing som biomarkör vid systemisk lupus erythematosus

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Lina Rehnman; [2022]
    Nyckelord :systemisk lupus erythematosus; SLE; alternativ splicing; transkription;

    Sammanfattning : Characteristics as unknown cause, complicated pathophysiology and a great amount of complexity are describing systemic lupus erythematosus (SLE) more than well. It’s an autoimmune disease that is almost exclusive for women in their reproductive years and are believed to correlate with both genetics and environmental factors. LÄS MER