Sökning: "Lipid formulation"
Visar resultat 1 - 5 av 9 uppsatser innehållade orden Lipid formulation.
1. Exploring alternative surfactants to replace PEG within lipid nanoparticles
Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master); Lunds universitet/Bioteknik (CI); Lunds universitet/Bioteknik (master)Sammanfattning : Over the past decade an increasing amount of studies has demonstrated that PEGylation not only precipitates reductions in drug delivery efficiency but also triggers the immune system to produce antibodies, specifically anti-PEG antibodies. The objective of my thesis is to explore alternative surfactants that could viably replace PEG within lipid nanoparticles. LÄS MER
2. Optimising microfluidic preparation of lipid sponge phase nanoparticles for biomolecule encapsulation
Master-uppsats, Lunds universitet/Kemiteknik (CI)Sammanfattning : Drug delivery with lipid nanoparticles, especially sponge phase lipid nanoparticles (LNP), has been well studied because of its ability for drug encapsulation and transferring the drug through the cell membrane. The sponge phase LNP formulation could be affected by the molecular structure of the lipid, the temperature, pH, dilution, the buffer, and the addition of a stabiliser. LÄS MER
3. Formulation and characterization of lipid-based nanocarriers for the delivery of antimicrobial peptide
Master-uppsats, KTH/ProteinvetenskapSammanfattning : Bakterier som är resistenta mot antibiotika har de senaste åren blivit ett stort hot mot mänskligheten. Att utveckla nya antibiotikaläkemedel är väldigt tidskrävande samt kommer med en dyr prislapp. LÄS MER
4. In vitro performance prediction of LBFs using lipolysis-permeation assay with the LiDo artificial membrane: Validation and protocol optimization
Master-uppsats, Uppsala universitet/Institutionen för farmaciSammanfattning : Lipid-based formulations (LBFs) can be an effective formulation strategy to improve the bioavailability of lipophilic drugs. However, conventional single-compartment in vitro lipolysis assays often underestimate LBF performance in vivodue to the absence of absorption sink. LÄS MER
5. Effect of lipid-based formulation on the solubilization patterns if poorly water-soluble drugs.
Master-uppsats, Uppsala universitet/Institutionen för farmaciSammanfattning : Poorly water-soluble drugs (PWSDs), to date, require advanced formulation techniques to improve solubility and achieve the required plasma concentration to show a therapeutic effect when orally administered. Lipid-based formulations (LBFs) are an enabling strategy that is being used to improve the oral delivery of PWSDs. LÄS MER