Sökning: "DPPC"

Visar resultat 1 - 5 av 6 uppsatser innehållade ordet DPPC.

  1. 1. Exploring alternative surfactants to replace PEG within lipid nanoparticles

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master); Lunds universitet/Bioteknik (CI); Lunds universitet/Bioteknik (master)

    Författare :Elina Edidovica; [2024]
    Nyckelord :Lipid nanoparticle; polyethelyne glycol PEG ; alpha-tomatine; N-hexadecyl beta d-maltoside HDM ; DOPC; DPPC; cholesterol; film hydration; stability study; DLS; Cryo-TEM; SAXS; pharmaceutical formulation; Chemistry;

    Sammanfattning : Over the past decade an increasing amount of studies has demonstrated that PEGylation not only precipitates reductions in drug delivery efficiency but also triggers the immune system to produce antibodies, specifically anti-PEG antibodies. The objective of my thesis is to explore alternative surfactants that could viably replace PEG within lipid nanoparticles. LÄS MER

  3. 2. Interaction between cobalt nanoparticles and DPPC at pulmonary conditions

    Master-uppsats, KTH/Yt- och korrosionsvetenskap

    Författare :Paula Sommer; [2021]
    Nyckelord :metallic nanoparticles; lipids; lung surfactants; adsorption; pulmonary fluid; metalliska nanopartiklar; lipider; lungtensider; adsorption; syntetisk lungvätska;

    Sammanfattning : Nanomaterial produceras och används alltmer i tekniska lösningar för att förbättra t.ex. materialegenskaper. Eftersom ett materials egenskaper förändras när det är i nanoskala så påverkas även dess toxikologiska egenskaper. LÄS MER

  4. 3. The influence of dissolution medium on in vitro dissolution profiles for pulmonary drug delivery

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Venus Zafranian; [2021]
    Nyckelord :Inhalation; in vitro dissolution; budesonide; fluticasone propionate; modified andersen cascade impactor; pulmonary drug delivery; dissolution profiles; dissolution medium;

    Sammanfattning : Today, orally inhaled drugs found on the market suffer from variable and discontinuous pulmonary drug release which lowers efficacy and patience compliance. This is usually a consequence of the poor understanding of the interaction and dissolution behavior of drug particles in the lung environment. LÄS MER

  5. 4. Formation of biological membranes

    L3-uppsats, Uppsala universitet/Molekyl- och kondenserade materiens fysik

    Författare :Rebecka Lexelius; [2020]
    Nyckelord :Molecular Dynamics; Lipids; DPPC; Biophysics;

    Sammanfattning : The amphiphilic property of phospholipids drives the spontaneous formation of various molecular aggregates in response to their surrounding environment. In this study the concentration of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) lipids in water was varied in order to investigate the naturally occurring arrangements over time, and specifically the propensity to form monolayers on the water-vacuum interface. LÄS MER

  7. 5. Synovial fluid components as synergistic lubricants in articular joint models

    Master-uppsats, KTH/Kemi

    Författare :Sixuan Li; [2019]
    Nyckelord :synergistic lubrication; synovial fluid; biolubrication; DPPC; hyaluronic acid; Mini-Traction Machine; macro- and microscale; profilometer;

    Sammanfattning : The excellent lubrication present within mammalian synovial joints attracted scientific interest, and some close-to-realistic models were applied to study the mechanism in vitro. In this project, the synergistic lubrication of synovial fluid was investigated by using 1,2-Dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), hyaluronic acid (HA), and phosphate-buffered saline (PBS buffer) to mimic the synovial fluid. LÄS MER