Sökning: "MAPK signaling pathway"

Hittade 5 uppsatser innehållade orden MAPK signaling pathway.

  1. 1. Gene expression of MAP2K1 and Cyclin D1 in BDII rat model of Endometrial cancer

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Almir Budnjo; [2016]
    Nyckelord :biomedicine; endometrial cancer; gene expression; qPCR; BDII rat model; MAP2K1; CCND1; MTS assay; cell culturing; Taqman; MAPK signaling pathway;

    Sammanfattning : Endometrial adenocarcinoma (EAC) is the most frequently diagnosed gynecological cancer of the female genital tract in the Western world. Research studies in EC is difficult to conduct on human tumor samples due to the complex nature of tumor arousal and genetic heterogeneousness in the human population. LÄS MER

  3. 2. Mathematical modeling of normal and cancer prostate signaling pathways

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Sofia Stamouli; [2015]
    Nyckelord :prostate cancer; MAPK pathway; prostate cancer signaling;

    Sammanfattning : The field of systems biology has become very popular as a means to deal with cancer as well as other complex biological issues. It enables scientists to gain an insight into difficult conditions through mathematical approaches that have been developed. LÄS MER

  4. 3. Role of MKP-2 in crosstalk between MAPK pathways

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Ludwiginstitutet för cancerforskning

    Författare :Mikaela Åhlin; [2015]
    Nyckelord :;

    Sammanfattning : Abnormalities in Mitogen Activated Protein Kinase (MAPK) signalling may affect the cells essential processes and influence the cell in acquiring traits to favour tumorigenic transformation and the progression of cancer. Deregulation of the MAPK pathways and uncontrolled crosstalk occurring in cancers may be caused by deregulation by MAP-kinase phosphatases (MKPs) that negatively regulates MAPKs by dephosphorylation. LÄS MER

  5. 4. Heme degradation pathway controls inflammation in model of mouse prostatitis

    Master-uppsats, Lunds universitet/Examensarbeten i molekylärbiologi

    Författare :Lisa Vikström; [2015]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Acute or chronic inflammation in the prostate is implicated in pathogenesis of benign prostate hyperplasia (BPH) as well as development of prostatic intraepithelial neoplasia (PIN) and prostate cancer (PCa). Chronic prostatitis (inflammation in the prostate) is associated with high morbidity and negatively impacts life quality. LÄS MER

  7. 5. Robustness Analysis of MAPK Signaling Cascades

    L3-uppsats, KTH/Reglerteknik

    Författare :Vladislav Nenchev; [2009]
    Nyckelord :robustness analysis; robustification; bistability; MAPK; biochemical;

    Sammanfattning : The MAPK cascade is responsible for transmitting information in the cytoplasm of the cell and regulating important fate decisions like cell division and apoptosis. Due to scarce experimental data and limited knowledge about many complex biochemical processes, existing MAPK pathway models, which exhibit bistability, have a significant structural uncertainty. LÄS MER