Sökning: "Raphaela Pensch"

Hittade 1 uppsats innehållade orden Raphaela Pensch.

  1. 1. Non-coding constraint mutations impact the gene regulatory system in osteosarcoma

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi; Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Raphaela Pensch; [2021]
    Nyckelord :cancer; osteosarcoma; cancer genomics; evolutionary constraint; non-coding mutations; gene regulation;

    Sammanfattning : The non-coding space makes up around 98 % of the genome, but cancer-driving mutations have so far mostly been discovered in protein-coding regions. The majority of somatic non-coding mutations are neutral passenger mutations and identifying non-coding mutations with driving roles in cancer poses a challenge. LÄS MER