Sökning: "ligand"

Visar resultat 21 - 25 av 148 uppsatser innehållade ordet ligand.

  1. 21. Crystallization, optimization, and crystal structure determination of ligands in complex with galectin-8N

    Kandidat-uppsats, Lunds universitet/Kemiska institutionen

    Författare :George Larsson; [2022]
    Nyckelord :Biochemistry; Structural Biochemistry; Galectin-8; Protein Crystallization; Chemistry;

    Sammanfattning : This thesis focuses on the protein “galectin-8N” which is a lectin protein that takes part in several physiological functions such as inflammation, autophagy, cell migration, and more. The project has three objectives: to observe and increase the reproducibility of crystallization of two variants (wildtype and mutant) of the human protein galectin-8N and to analyze the binding site when three different novel ligands are each inserted. LÄS MER

  3. 22. Drug Design of β-Lactamase Inhibitors of the DBO-scaffold against OXA-48 : A Molecular Dynamics Study of Ligand Stability in the Michaelis Complex

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Läkemedelsdesign och läkemedelsutveckling

    Författare :Linda Liljeholm; [2022]
    Nyckelord :OXA-48; β-lactamase; DBO inhibitors; diazabicyclooctane; avibactam; relebactam; β-lactamase inhibitor; BLI; molecular dynamics; LIE; Linear Interaction Energy; antibiotic resistance; drug design;

    Sammanfattning : The emergence of β-lactamase-mediated antibiotic resistance is one of the biggest threats in modern times. Combined with the discovery void of new forms of antibiotics, this sets the course toward a future where the efficacy of present-day health care will be jeopardized. LÄS MER

  4. 23. Influence of The Heavy Atom Effect on The Cage Escape Yields of Iron(III)-Photosensitizers with N-Heterocyclic Carbene Ligands

    Master-uppsats, Uppsala universitet/Fysikalisk kemi

    Författare :Johannes Wega; [2022]
    Nyckelord :;

    Sammanfattning : The recent emergence of earth-abundant iron(III)-photosensitizers with N-heterocyclic carbene ligands, exhibiting nanosecond ligand-to-metal charge-transfer states with suitable redox potentials to activate a broad range of substances, offers the possibility to convert sunlight into chemical substances, such as fuels or pharmaceuticals, in an environmentally friendly way. These complexes, however, often suffer from low yields of charge-separated products escaping the solvent cage, making such applications inherently inefficient. LÄS MER

  5. 24. Synthesis of a rotaxane with switchable lanthanide luminescence

    Master-uppsats, KTH/Organisk kemi

    Författare :Anja Ramström; [2022]
    Nyckelord :mechanically interlocked molecules; supramolecular chemistry; luminescence; rotaxanes; lanthanides; mekaniskt sammankopplade molekyler; supramolekylär kemi; luminescens; rotaxaner; lantanider;

    Sammanfattning : I rotaxaner följs förflyttningen av makrocykeln vanligtvis med 1H-NMR spektroskopi. Målet med detta projekt är i stället att utveckla ett system som möjliggör att förflyttningen av makrocykeln kan observeras med hjälp av luminiscerande lantanid emission. LÄS MER

  7. 25. Orphan G-Protein Coupled Receptors : Can we deorphanize the remaining orphans despite all the challenges?

    Kandidat-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi

    Författare :Micaela Andersson; [2022]
    Nyckelord :Deorphanization; Heterodimerization; High-throughput screening; Orphan G-protein Coupled receptor; Pseudogenes; Reversed pharmacology;

    Sammanfattning : G-protein coupled receptors (GPCRs) play a key role in a broad range of biological processes by binding to a wide variety of signaling molecules, which have resulted in 34% of all FDA-approved drugs which target GPCRs. The human genome encodes for approximately 800 GPCR members of which about 140 non-olfactory receptors remain orphans with an unknown function and endogenous ligand. LÄS MER