Sökning: "ligand"

Visar resultat 16 - 20 av 148 uppsatser innehållade ordet ligand.

  1. 16. Learning the shapes of protein pockets

    Master-uppsats, Göteborgs universitet/Institutionen för data- och informationsteknik

    Författare :Alejandro Corrochano; Yossra Gharbi; [2022-10-14]
    Nyckelord :Protein; cavity; ligand-binding; 3D-equivariance; shape; latent space; e3nn; Fpocket; sc-PDB;

    Sammanfattning : The comparison of protein pockets plays an important role in drug discovery. Through the identification of binding sites with similar structures, we can assist in finding hits and characterizing the function of proteins. Traditionally, the geometry of cavities has been described with scalar features, which are not fully representative of the shape. LÄS MER

  3. 17. Diffusion and Camera-Noise Modelling for Analysis of Single-Particle Tracking Movies

    Master-uppsats, Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

    Författare :Erik Clarkson; [2022]
    Nyckelord :reaction-diffusion; camera-noise modelling; single-particle tracking; Gillespie simulations; Physics and Astronomy;

    Sammanfattning : Interactions between T-cells and other body cells is an essential part of the immune system. It involves the binding between surface receptors of the two cells. Specifically, T-cell receptors (TCRs) bind onto pMHC (peptide-loaded major histocompatibility complex) molecules on the partnering cell surface. LÄS MER

  4. 18. The Binding Mechanism of Carbapenems in the Class A beta-lactamase IMI-1 : A Molecular Dynamics Study of Ligand Stability

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Biokemi

    Författare :Isabell Lindahl; [2022]
    Nyckelord :antibiotic resistance; IMI-1; betalactamase; Carbapenemase; free energy; LIE; linear interaction energy; β-lactamase; meropenem; biapenem; imipenem; active site;

    Sammanfattning : Antibiotic resistance is a global and accelerating matter. Over time, the bacteria have evolved several defense mechanisms against the antibiotics. One of the defense mechanisms is that the bacteria can produce enzymes with the ability to hydrolyze the characteristic b-lactam ring of the antibiotics. These enzymes are called b-lactamases. LÄS MER

  5. 19. Exploring Regioselective 5N-acylation of Neuraminic acid

    Master-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Simon Hans Lilje; [2022]
    Nyckelord :acylation; amide; antibacterial drugs; regioselective deprotection; sialic acid; organic chemistry; Chemistry;

    Sammanfattning : In this project, a regioselective method to deprotect and acylate the amide on C5 of sialic acid is explored. Sialic acid is one of the most complex monosaccharides and is an important ligand in many higher organisms in intercellular cell communication. The most prominent example is related to the immune system. LÄS MER

  7. 20. Modulation of a model ligand-gated ion channel by amphetamine derivatives

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Strukturbiologi

    Författare :Emelia Karlsson; [2022]
    Nyckelord :pentameric ligand-gated ion channels; sTeLIC; electrophysiology; psychostimulants; amphetamine derivatives;

    Sammanfattning : Pentameric ligand-gated ion channels are critical mediators of electrochemical signal transduction in neurons and other excitable cells, causing them to be important targets of psychoactive drugs. Structural data for these complex proteins are limited, particularly among eukaryotic family members and for the functionally critical open state. LÄS MER