Sökning: "methylation"

Visar resultat 1 - 5 av 58 uppsatser innehållade ordet methylation.

  1. 1. Impact of BPA, BPF and Mixture N1 on DNA-Methylation of GRIN2B and NR3C1 during human neuroprogenitor cell differentiation

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Fysiologi och miljötoxikologi

    Författare :Franziska Sophie Richter; [2023]
    Nyckelord :Epigenetics; Endocrine disrupting chemicals; DNA methylation; EDCs; Mixture effects; BPA; BPF; Mixture N1;

    Sammanfattning : Endocrine disrupting chemicals (EDCs) are ubiquitous and their adverse impact on nature, wildlife and humans is extensively researched. We are constantly exposed to EDCs, such as the widespread and extensively researched Bisphenol A, as well as its substitute Bisphenol F, which is coming into wider use, even though it is much less is researched and limited information is available about its endocrine effects. LÄS MER

  3. 2. Analys av DNA-metylering i genen CREBBP och dess koppling till autism

    Kandidat-uppsats, KTH/Medicinteknik och hälsosystem

    Författare :Karolina Söderberg; Sofie Fröjdman; [2023]
    Nyckelord :Methylation; autism; Matlab; DNA; CREBBP; DNA-sequencing; Metylering; autism; Matlab; DNA; CREBBP; DNA-sekvensering;

    Sammanfattning : Autism är en neuropsykiatrisk funktionsnedsättning som i olika utsträckning påverkar individens sätt att tänka, vara och kommunicera. Arv har visat sig vara en betydande faktor till varför vissa får autism, och forskning tyder på att det finns ett samband mellan autism och en obalans i metyleringsmönstret i vissa gener. LÄS MER

  4. 3. Identification of epigenetic biomarkers associated with the development of diabetic kidney disease in individuals with type 2 diabetes: a nested cohort study

    Master-uppsats, Lunds universitet/Socialmedicin och global hälsa

    Författare :Marian Paiva Marchiori; [2023]
    Nyckelord :Medicine and Health Sciences;

    Sammanfattning : Introduction. Type 2 diabetes (T2D) is the most common type of diabetes, and it can cause complications such as diabetic kidney disease (DKD), the main cause of end-stage renal disease worldwide. There is an urgent need to develop new biomarkers that would improve DKD’s risk prediction in patients with T2D. LÄS MER

  5. 4. Newly inundated forest landscapes - hotspots for mercury in water and benthic fauna

    Master-uppsats, SLU/Dept. of Aquatic Sciences and Assessment

    Författare :Kirstine Evald Andersson; [2023]
    Nyckelord :Wetland restoration; Inundation; Mercury cycling; Beaver impoundments; Aquatic biogeochemis-try;

    Sammanfattning : Mercury (Hg) is a widespread contaminant in high-latitude aquatic ecosystems, where it can undergo microbial transfor-mation into toxic methylmercury (MeHg). Due to its chemical properties, MeHg tends to accumulate in the aquatic food chain and will eventually end up in predatory species at the top of the terrestrial food web. LÄS MER

  7. 5. Non-coding RNAs as therapeutic agents : The future of therapy

    Kandidat-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Hederoth Gustaf; Lyngå Olivia; Rudqvist Olivia; Jeppsson Rebecka; Hogolof Saida; Svanberg Sara; Kauppinen Veera; [2022]
    Nyckelord :Non-coding RNA; Oligonucleotide therapeutics;

    Sammanfattning : Non-coding RNA (ncRNA) therapeutics are based on short oligonucleotides, both naturally occurring and artificial, which target RNA in a site-specific way to modulate gene expression. As of today, 12 synthetically produced ncRNA-based drugs are available on the market in the US and Europe, and there is a possibility of more to be approved in the near future. LÄS MER