Sökning: "Metabolites"

Visar resultat 1 - 5 av 197 uppsatser innehållade ordet Metabolites.

  1. 1. OPTIMIZATION OF CLONE SELECTION PLATFORM FOR PRODUCTION OF RECOMBINANT PROTEINS

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Basel Yousef; [2024]
    Nyckelord :;

    Sammanfattning : Background  Biologics are type of proteins that can be produced by expression in a foreign host for medical healthcare applications in humans. Monoclonal antibodies (mAbs) are type of biologics that are designed to specifically bind to one target, with a purpose to inhibit a certain molecule that could be associated with a disease process. LÄS MER

  3. 2. Impact of nitrogen availability and nitrogen structural composition on fungal enzymatic activity and growth : how nutrient availability governs response and development of three saprotrophic Basidiomycetes

    Master-uppsats, SLU/Dept. of Soil and Environment

    Författare :Bella Strid; [2024]
    Nyckelord :nitrogen; tannins; condensed tannins; MnP; manganese peroxidase; peptidase; saprotrophic basidiomycetes;

    Sammanfattning : Fungi excrete a wide variety of extracellular enzymes to scavenge for nutrients, such as the often scarce yet essential nutrient nitrogen. All fungi produce highly specialized hydrolytic enzymes, e.g. peptidases, that depolymerize organic molecules. LÄS MER

  4. 3. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemi

    Författare :Maryam Dost; [2024]
    Nyckelord :Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Sammanfattning : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. LÄS MER

  5. 4. Leveraging CNN for Automated Peak Picking in Untargeted Metabolomics without Parameter Dependencies

    Master-uppsats, Göteborgs universitet/Institutionen för data- och informationsteknik

    Författare :Vivian Wang; Lidia Yalew; [2023-10-19]
    Nyckelord :Deep learning; Convolutional neural network; LC-MS; Peak Detection; Metabolomics; Faster R-CNN;

    Sammanfattning : Metabolomics is a scientific discipline that involves the thorough analysis of small molecules, known as metabolites, found within a biological system. Furthermore, liquid chromatography-mass spectrometry (LC-MS) is a commonly used analytical technique in metabolomics for analysing biological samples due to its broad coverage of the measurable metabolome. LÄS MER

  7. 5. Cloning and expressing the genes encoding Glycerol dehydratase (GDHt) and 1,3-Propanediol dehydrogenase (1,3-PDDH) in E. coli

    Master-uppsats, Lunds universitet/Bioteknik (master); Lunds universitet/Bioteknik (CI)

    Författare :Eleni Pechlivani; [2023]
    Nyckelord :1; 3-Propanediol; Glycerol dehydratase; 3-Propanediol dehydrogenase; Glycerol dehydratase reactivase; E. coli; Protein expression; Biotechnology; Technology and Engineering;

    Sammanfattning : The biodiesel sector has witnessed tremendous growth in recent years, leading to a significant increase in glycerol production as a by-product. Addressing the challenge of glycerol valorization is crucial for the sustainability of the biodiesel industry. LÄS MER