Sökning: "NONMEM"

Visar resultat 6 - 10 av 10 uppsatser innehållade ordet NONMEM.

  1. 6. Individualization of fixed-dose combination regimens : Methodology and application to pediatric tuberculosis

    Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Gunnar Yngman; [2015]
    Nyckelord :pharmacometrics; pharmacokinetics; PK; population pharmacokinetics; optimal design; FDC; fixed-dose combination; pediatrics; tuberculosis; rifampicin; pyrazinamide; isoniazid; ethambutol; modeling; simulation; estimation; allometric scaling; stochastical simulation and estimation; NONMEM; MATLAB; FO; FOCE; Expectation-Maximization algorithm; importance sampling; Nelder-Mead method; logistic function; discontinuity; euclidean distance; Sammon mapping; global minimum; local minima;

    Sammanfattning : Introduction: No Fixed-Dose Combination (FDC) formulations currently exist for pediatric tuberculosis (TB) treatment. Earlier work implemented, in the software NONMEM, a rational method for optimizing design and individualization of pediatric anti-TB FDC formulations based on patient body weight, but issues with parameter estimation, dosage strata heterogeneity and representative pharmacokinetics remained. LÄS MER

  3. 7. Predictability and performance of different non-linear mixed-effects models for HbA1c in patients with type 2 diabetes mellitus

    Master-uppsats, Institutionen för farmaceutisk biovetenskap; Institutionen för biologisk grundutbildning

    Författare :Gustaf Wellhagen; [2014]
    Nyckelord :Type 2 diabetes mellitus; semi-mechanistic models; HbA1c; glucose; insulin; NONMEM;

    Sammanfattning : To accurately predict the outcome of a late phase study, pharmacometric models can help in drug development. Making informed decision on which models to use will also facilitate drug development. This can depend on the mechanism of action for the drug as well as stability and runtime factors. LÄS MER

  4. 8. Standard two-stage and Nonlinear mixed effect modelling for determination of cell-to-cell variation of transport parameters in Saccharomyces cerevisiae

    Master-uppsats, Reglerteknik; Tekniska högskolan

    Författare :David Janzén; [2012]
    Nyckelord :Systems biology; mathematical modelling; profile likelihood; cell-to-cell variation; STS; NONMEM; Saccharomyces cerevisiae;

    Sammanfattning : The interest for cell-to-cell variation has in recent years increased in a steady pace. Several studies have shown that a large portion of the observed variation in the nature originates from the fact that all biochemical reactions are in some respect stochastic. LÄS MER

  5. 9. PKPD models for colistin and meropenem on a wild-type and a resistant strain of Pseudomonas aeruginosa

    Uppsats för yrkesexamina på avancerad nivå, Institutionen för farmaceutisk biovetenskap

    Författare :Jonathan Lyly; [2011]
    Nyckelord :meropenem; colistin; pseudomonas aeruginosa; models; pharmacometric models; pharmacokinetic models; PKPD;

    Sammanfattning : Resistant bacteria are becoming more and more of a problem but treatment with antibiotics in combination may overcome and prevent resistance development. The combination of meropenem and colistin against Pseudomonas aeruginosa has been proposed as a promising treatment to increase the bactericidal effect and a synergistic effect has been proposed. LÄS MER

  7. 10. Design of Class Structures and Inter Class Communication Interface : Computer Methods used in Non-linear Mixed Effects Modeling

    Magister-uppsats, Institutionen för informationsteknologi

    Författare :Pontus Pihlgren; [2008]
    Nyckelord :;

    Sammanfattning : The field of pharmacokinetics and pharmacodynamics describes the interactionbetween drugs and the human body from the time the drug is absorbed in the blood stream, distributed in the body, metabolized and finally excreted. The behavior can be described with nonlinear mixed effects models. LÄS MER