Sökning: "cancer genetics"

Visar resultat 1 - 5 av 13 uppsatser innehållade orden cancer genetics.

  1. 1. Alternativ Splicing som biomarkör vid systemisk lupus erythematosus

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Lina Rehnman; [2022]
    Nyckelord :systemisk lupus erythematosus; SLE; alternativ splicing; transkription;

    Sammanfattning : Characteristics as unknown cause, complicated pathophysiology and a great amount of complexity are describing systemic lupus erythematosus (SLE) more than well. It’s an autoimmune disease that is almost exclusive for women in their reproductive years and are believed to correlate with both genetics and environmental factors. LÄS MER

  3. 2. Cancer Driver Gene Detection using Deep Convolutional Neural Networks on H3K4me3 Enrichment Profiles

    Master-uppsats, Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation

    Författare :Marc Pielies Avellí; [2022]
    Nyckelord :Cancer Driver CD Gene; Histone Post-Translational Modifications PTMs ; Convolutional Neural Networks CNNs .; Physics and Astronomy;

    Sammanfattning : In spite of our current knowledge regarding the biology underlying cancer genesis, reliable methods for the discovery of cancer driver (CD) genes are still in great need. The rather recent incorporation of epigenetic markers to the cancer paradigm has nevertheless opened the door for the development of new computational approaches to the problem. LÄS MER

  4. 3. Identification of novel loss of heterozygosity collateral lethality genes for potential applications in cancer

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Margus Veanes; [2021]
    Nyckelord :biology; oncology; structural; genetics; bioinformatics; cancer;

    Sammanfattning : Over the course of this project, I demonstrate the utility of a 4-phase analysis pipeline in the context of cancer therapy and the associated search for antineoplastic drug candidates. I showcase a repeatable means for generating lists of potential targets which may be used in conjunction with methods like small molecule screening as part of a search for broadly effective antineoplastic agents. LÄS MER

  5. 4. Cost-Effectiveness of Surveillance Programs of Carriers of Pathogenic Mutations in the TP53-Gene in Sweden

    Magister-uppsats, Linköpings universitet/Nationalekonomi

    Författare :Oskar Frisell; [2020]
    Nyckelord :TP53 Surveillance Cost-effectiveness Genetics;

    Sammanfattning : Introduction: Pathogenic mutations in the TP53-gene is present in about 50% of all somatic cancers. The TP53 gene’s function is to stop cancer cells from dividing, thus protect us from cancer. When this gene is not functioning properly, carriers face 70-100% risk of developing cancer in their lifetime. LÄS MER

  7. 5. Epigenetiskt arv

    Kandidat-uppsats, SLU/Dept. of Animal Breeding and Genetics

    Författare :Moa Lindell; [2019]
    Nyckelord :epigenetik; epigenetisk nedärvning; epigenetiska mekanismer;

    Sammanfattning : Epigenetik är den del av genetiken som behandlar förändringar i genuttryck som är oberoende av förändringar i DNA-sekvensen. Det som styr vilka gener som uttrycks och får effekt på fenotyp har studerats av forskare sedan 70-80-talet. LÄS MER