Sökning: "dissociation constant Kd"

Visar resultat 1 - 5 av 6 uppsatser innehållade orden dissociation constant Kd.

  1. 1. Biophysical characterization of and screening for binders and potentiator compounds that modulate the binding of PDZ domains to the C-terminal peptide motifs of target proteins

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Carl Olsson; [2021]
    Nyckelord :Post synaptic density protein 95; PDZ-domains; N-methyl-D-aspartate receptor; NMDAR hypofunctional hypothesis; GluN2b; Differential scanning fluorimetry; Surface plasmon resonance; Fragment based drug design; Assay development;

    Sammanfattning : The N-methyl-D-aspartate receptor (NMDAR) hypofunctional hypothesis is believed to explain one of the contributing factors to schizophrenia. This hypothesis suggests the dysregulation of NMDAR, a protein responsible for receiving signals from the synapses between neurons, is the cause of some of the symptoms seen in schizophrenia. LÄS MER

  3. 2. Fragment screening using WAC towards new SMARCA4 inhibitors

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Artur Sahakjan; [2020]
    Nyckelord :WAC; Fragments; SMARCA4; Library; Fragment Based Drug Discovery FBDD ; Peptide Synthesis; Affinity; Organic chemistry; Organisk kemi; Chemistry;

    Sammanfattning : The drug discovery and development process has changed dramatically during the last decades and the growth of more efficient techniques as high throughput screening combined with combinatorial synthesis using amino acids and carboxylic acids on solid support makes it possible to investigate the affinity of molecules towards a biological target. Fragment based drug discovery (FBDD) has been implemented into different techniques with purpose of discovering new drugs. LÄS MER

  4. 3. Interactions of the Human Recombinant Proteins JUNO and IZUMO1

    Kandidat-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Emma Lundell; [2020]
    Nyckelord :male infertility; surphace plasmon resonance; protein interactions; gold nanoparticles; protein immobilization; manlig infertilitet; ytplasmonresonans; proteininteraktioner; guldnanopartiklar; proteinimmobilisering;

    Sammanfattning : Det uppskattas att 15% av alla par världen över lider avinfertilitet. Ungefär hälften beror på manlig infertilitet och 40% av dessa fall kan ännu inte förklaras. Därmed är nuvarande metoder för att diagnostisera manlig infertilitet otillräckliga och ytterligare tekniker behövs. LÄS MER

  5. 4. Modelling antibody orientation at bacterial surfaces

    Kandidat-uppsats, Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

    Författare :Vibha Kumra; [2017]
    Nyckelord :Physics and Astronomy;

    Sammanfattning : Bacteria and humans have co-evolved since their common existence. They have thereby developed very specific defence and target mechanisms against one another. Understanding the complex biomolecular processes behind these interactions can be of great use for developing treatments against bacterial diseases. LÄS MER

  7. 5. Structure and function of a bacterial redox sensor.

    Master-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Marwaa Ahmad; [2016]
    Nyckelord :Rex protein; Microscale thermophoresis MST ; dissociation constant Kd ; protein science; proteinvetenskap; Biology and Life Sciences; Chemistry;

    Sammanfattning : Gram-positive bacteria e.g. Streptomyces coelicolor [8], Bacillus subtilis [43] and Staphylococcus aureus [40] contain a novel sensor for the nicotinamide adenine dinucleotide (NAD) redox balance that functions as a transcriptional repressor called Rex (redox). Rex plays a key role in regulating genes in energy metabolism. LÄS MER