Sökning: "drug stability"

Visar resultat 1 - 5 av 40 uppsatser innehållade orden drug stability.

  1. 1. Exploring alternative surfactants to replace PEG within lipid nanoparticles

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master); Lunds universitet/Bioteknik (CI); Lunds universitet/Bioteknik (master)

    Författare :Elina Edidovica; [2024]
    Nyckelord :Lipid nanoparticle; polyethelyne glycol PEG ; alpha-tomatine; N-hexadecyl beta d-maltoside HDM ; DOPC; DPPC; cholesterol; film hydration; stability study; DLS; Cryo-TEM; SAXS; pharmaceutical formulation; Chemistry;

    Sammanfattning : Over the past decade an increasing amount of studies has demonstrated that PEGylation not only precipitates reductions in drug delivery efficiency but also triggers the immune system to produce antibodies, specifically anti-PEG antibodies. The objective of my thesis is to explore alternative surfactants that could viably replace PEG within lipid nanoparticles. LÄS MER

  3. 2. Evaluation of different block-copolymer coatings of iron oxide nanoparticles by flash nanoprecipitation

    Master-uppsats, KTH/Fiber- och polymerteknologi

    Författare :Felix Bogdan; [2023]
    Nyckelord :Nanopartiklar; organisk katalysator; ROP; block-sampolymerer PL G A; oljesyra IONPs; Nanoparticles; organic catalyst; ROP; block-copolymers PL G A; oleic acid IONPs;

    Sammanfattning : Nanopartiklar (NP) erbjuder unika möjligheter för medicinska tillämpningar, inklusive kontrollerad frisättning av cancerläkemedel, användning som bildkontrast vid avbildningsprocedurer eller hypertermisk behandling av cancerceller. Flash nanoprecipitation (FNP) producerar NPs för att kombinera dessa tillämpningar i en snabb, billig och skalbar beläggningsprocess. LÄS MER

  4. 3. Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Theranostics

    Författare :Astrid Haraldsson; [2023]
    Nyckelord :PNA; pretargeting; cancer therapy; cytotoxic payload;

    Sammanfattning : One of the major challenges in cancer treatment is delivering high enough doses of active substance specifically to cancer cells without accumulation in healthy organs. Pretargeting has emerged as a potential solution, where the delivery of a cancer recognizing (primary) agent and a cancer killing (secondary) agent are separated. LÄS MER

  5. 4. The Potential Use of Degradable Starch Microspheres as a Carrier for Nasal Drug Administration

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Rojda Unal; [2023]
    Nyckelord :Pharmaceutical technology; Nasal administration; Läkemedel; Pulverformiga bärare; Sfärer; Pulverinhalation; Bärarmaterial; Läkemedelseffektivitet; Pulverteknik; Partikelformulering; Nasal deposition; Biology and Life Sciences;

    Sammanfattning : Intranasal drug delivery is a practical and accessible method for treating localized symptoms as well as achieving systemic drug absorption. The approach takes advantage of the permeability, vascularization, and limited enzymatic activity of nasal tissue, leading to enhanced drug absorption. LÄS MER

  7. 5. Negotiating Unwanted Outsider Status- A study of Gang Subculture among Rohingya Refugees in Bangladesh

    Master-uppsats, Lunds universitet/Sociologi; Lunds universitet/Sociologiska institutionen

    Författare :Sourav Das; [2023]
    Nyckelord :Rohingya; Rohingya Refugees; Gangs; Refugee Gang; Deviant Subculture; Gang Subculture; Moral Panic; Folk devils; Law and Political Science; Cultural Sciences; Social Sciences;

    Sammanfattning : The emergence of the refugee gang subculture has changed its focus from being a regional to a worldwide problem, drawing on the findings of previous studies. Many past studies suggest that the massive influx of Rohingya refugees from Myanmar has not only amplified existing socioeconomic challenges but has also fueled concerns within the host population in Bangladesh regarding organized gang violence. LÄS MER