Sökning: "neural progenitor cells"

Visar resultat 6 - 10 av 12 uppsatser innehållade orden neural progenitor cells.

1. 6. Epigenetic and transcriptional effects of full-length LINE-1 retrotransposons in human neural progenitor cells

   Master-uppsats, Lunds universitet/Examensarbeten i bioinformatik

   Författare :Ninoslav Pandiloski; [2021]
   Nyckelord :Biology and Life Sciences;

   Sammanfattning : Transposable elements (TE) are parasitic genetic entities that have the ability to alter their position within a genome and have the potential to influence its functionality. Although TEs play beneficial roles in the evolution of their host, they are active in various human disorders including neurological diseases, where may contribute to the progress of the disease. LÄS MER

3. 7. Do Nanoparticles Affect Neuronal Function? - Establishment of a Microelectrode-Based Assay

   Master-uppsats, Lunds universitet/Tillämpad biokemi

   Författare :Markus Nylander; [2020]
   Nyckelord :Microelectrode array; gold nanoparticles; silver nanoparticles; immunocytochemistry; scanning electron microscopy; human neural progenitor cells; human induced pluripotent stem cells; applied biochemistry; tillämpad biokemi; Biology and Life Sciences; Technology and Engineering;

   Sammanfattning : Nanomaterials are used extensively in industry and daily life but comparatively little is known about the possible health effects. Silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) are two metal nanoparticles that have been intensively studied. LÄS MER

4. 8. How Topography Influences the Fate of Human Neural Progenitor Cells

   Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

   Författare :Jacob Karlström; [2020]
   Nyckelord :biomaterials; cell culture; electrospinning; nanofibers; 3d; neural progenitor cells; in vitro models; nanotopography; blebbistatin; mechanotransduction; nucleus analysis; immunocytochemistry; differentiation; applied biochemistry; tillämpad biokemi; Biology and Life Sciences; Technology and Engineering;

   Sammanfattning : Novel biomimetic three-dimensional scaffolds have emerged over the last decades, and are promising for applications in regenerative therapies, as well as in in vitro disease modelling and drug testing. Thanks to their added dimension, these scaffolds are able to more accurately mimic the topography of native cellular microenvironments compared to traditionally used two-dimensional culture substrates. LÄS MER

5. 9. Effects of Different Laminins on Human Neural Progenitor Cells Cultured in 3D Electrospun Fibers

   Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

   Författare :Karl Vesterlund; [2019]
   Nyckelord :two-dimensional; three-dimensional; Alamar Blue; cell culture; drug development; extra-cellular matrix; electrospinning; immunocytochemistry; laminin; polycaprolactone; polymerase chain reaction; western blot; applied biochemistry; tillämpad biokemi; Technology and Engineering; Biology and Life Sciences;

   Sammanfattning : A low success rate of drug candidates in clinical trials, and especially in brain research, motivates development of better screening models. Hence, in neuroscience and many other fields of Life Science, development of more physiological relevant experimental cell-based models is motivated. LÄS MER

7. 10. CRISPR/Cas9 gene-editing in an in vitro model of a familial form of ALS

   Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

   Författare :Fredrik Nilsson; [2018]
   Nyckelord :ALS; SOD1; Amyotrophic lateral sclerosis; superoxide dismutase; CRISPR Cas9; sgRNA; stem cell; lentivirus; qPCR; FOXG1; nestin; immunocytochemistry; differentiation; forebrain neural progenitor; Applied Biochemistry; Biology and Life Sciences;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease characterized by the degeneration and death of both upper and lower motor neurons for which there is no cure currently available. The degeneration of motor neurons leads to the inability to carry out voluntary movement and death usually occurs 3-5 years after disease onset by respiratory failure. LÄS MER