Sökning: "pluripotency"

Hittade 5 uppsatser innehållade ordet pluripotency.

  1. 1. PAMPaR: Parallel Analysis of miRNAs, Proteins and RNAs. Dynamic Profiles of miRNAs, mRNAs and Specific Proteins in Mouse Embryonic Stem Cells Differentiating into Neural Precursors

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Amelie Carlström; [2023]
    Nyckelord :PAMPaR; SPARC; Proximity extension assay; Neuronal differentiation; Mouse embryonic stem cells; PAMPaR; SPARC; Proximity extension assay; Neuronal differentiering; embryonala musstamceller;

    Sammanfattning : MikroRNA-molekyler (miRNA) är viktiga icke-kodande RNA-molekyler för post-transkriptionell reglering av proteinkodande gener. De har även effekter på många cellulära processer såsom differentiering. De biosyntetiska reaktioner som skapar miRNA involverar proteiner som själva regleras av miRNA. LÄS MER

  3. 2. Generation of induced pluripotent stem cells (iPSCs) lines deficient for genes associated with neurodevelopmental diseases using CRISPR/Cas9 technology

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Claudia De Guidi; [2021]
    Nyckelord :;

    Sammanfattning : Induced pluripotent stem cells (iPSCs) can self-renew and differentiate into many other cell types. IPSCs are derived from somatic cells, and upon reprogramming, they share an expression profile similar to embryonic stem cells (ESCs). LÄS MER

  4. 3. Identifying Cell Reprogramming Roadblocks by Modelling Induced Pluripotency with Boolean Networks and Dynamical Systems

    Master-uppsats, Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation; Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

    Författare :Johannes Isaksson; [2018]
    Nyckelord :Stem cells; pluripotency; pluripotent; reprogramming; iPS; induced pluripotency; Boolean; dynamical systems; network.; Medicine and Health Sciences;

    Sammanfattning : The generation of induced pluripotent stem (iPS) cells from differentiated cells is a process of great scientific interest due to the medical potential of such cells. This process (called 'reprogramming' of cells) is however notoriously inefficient and still not very well understood. LÄS MER

  5. 4. Metoder som minskar bildning av teratom vid in vivo transplantation av inducerade pluripotenta celler

    Kandidat-uppsats, SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Författare :Therese de Haan; [2013]
    Nyckelord :inducerade pluripotenta celler; iPS-celler; pluripotens; teratom; cancerceller; virala; vektorer; transgener; Oc3 4; Klf4; Sox2; c-Myc;

    Sammanfattning : Inducerad pluripotens innebär att man inducerar mogna celler till att övergå i ett pluripotent stadium och bilda så kallade inducerade pluripotenta celler (iPS-celler). Detta görs till exempel genom viral integration av transkriptionsfaktorerna octamer-binding transcription factor 3 och 4 (Oct3/4), sex determining region Y-box 2 (Sox2), Krüppel-like factor 4 (Klf4) och c-Myc. LÄS MER

  7. 5. Bioinformatics analysis of ZBED6 : interactome of Novel Transcription Factor ZBED6 in C2C12 Myoblasts

    Master-uppsats, SLU/Dept. of Animal Breeding and Genetics

    Författare :Awaisa Ghazal; [2010]
    Nyckelord :Ingenuity Pathway Analysis IPA ; C2C12 myoblasts; Chromatin Immunoprecipitation ChIP ; Microarray; Myogenesis; ZBED6;

    Sammanfattning : ZBED6 is a novel mammalian transcription factor that was recently identified and shown to act as a repressor of IGF2 transcription in skeletal muscle. Chromatin Immunoprecipitation (ChIP) sequence data in murine C2C12 myoblasts indicated that ZBED6 holds 2499 targeting sites. LÄS MER