Sökning: "Biopharmaceutical"

Visar resultat 1 - 5 av 30 uppsatser innehållade ordet Biopharmaceutical.

  1. 1. Method for separation of mono-, and di-saccharides with microchip capillary electrophoresis

    Master-uppsats, KTH/Tillämpad fysikalisk kemi

    Författare :Filip Friberg; [2023]
    Nyckelord :capillary electrophoresis; saccharide; cell culture; biopharmaceutical; microchip; kapillärelektrofores; sackarid; cellodlingsmedium; bioläkemedel; mikrochip;

    Sammanfattning : Biologiska läkemedel är läkemedel som tillverkas från cellodling och är en växande industri. Varje år tillverkas nya biologiska läkemedel, vilket ställer högre krav på metoder för att kunna mäta och kontrollera processparametrar av tillverkningen. LÄS MER

  3. 2. Signal amplification in a microfluidic immunoassay system via Binding Oligo Ladder Detection : Applying the Exazym® signal amplification to the Gyrolab® platform

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Daniel Wiman; [2023]
    Nyckelord :immunoassay; ultra-sensitive; signal amplification; Gyrolab; Exazym; high sensitivity; microfluidics; BOLD amplification; nucleic acid polymerisation;

    Sammanfattning : Immunoassays are analytical methods that use the highly specific binding of antibodies in order to detect and quantify an analyte. The technique has become a staple in modern biopharmaceutical research and diagnostics, however the measurement of biomarkers like dysregulated cytokines require ultra-sensitive immunoassays that can detect molecules at sub pg/mL concentrations. LÄS MER

  4. 3. Influence of Peristaltic Pump Tubes on Protein Particles Formation for Lipase Enzyme Therapeutic Protein

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Salah Elden Omer; [2023]
    Nyckelord :Dynamic Image analysis; Protein aggregation; Peristaltic pump tubing; Particle characterization; PVC tubing; Silicone tubing; Surfactant; QICPIC; Pharmaceutical technology; Biology and Life Sciences;

    Sammanfattning : Introduction: In Bio-pharmaceutical production, peristaltic pump tubing is considered one of the factors that influence protein aggregation. Background: Protein particles present challenges for the control and analysis of various manufacturing processes in the biopharmaceutical industry for their significant effects on safety and quality. LÄS MER

  5. 4. Explainable Machine Learning for Lead Time Prediction : A Case Study on Explainability Methods and Benefits in the Pharmaceutical Industry

    Master-uppsats, KTH/Hållbar produktionsutveckling (ML)

    Författare :Paul Fussenegger; Niklas Lange; [2022]
    Nyckelord :Lead time; machine learning; explainability; regression analysis; production planning and control; Ledtid; maskininlärning; förklarbarhet; regressionsanalys; produktionsplanering och produktionsstyrning;

    Sammanfattning : Artificial Intelligence (AI) has proven to be highly suitable for a wide range of problems in manufacturing environments, including the prediction of lead times. Most of these solutions are based on ”black-box” algorithms, which hinder practitioners to understand the prediction process. LÄS MER

  7. 5. Quality and Regulatory Issues Related to Continuous Manufacturing of Biologics

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Sorosh Ziarati; [2022]
    Nyckelord :Continuous Manufacturing; Regulation; Continuous freeze drying; Biopharmaceutical; Trastuzumab; Pharmaceutical Technology; Technology and Engineering;

    Sammanfattning : Introduction: Continuous Manufacturing involves the continuous feeding of input materials into the transformation of in-process materials within, and the concomitant removal of output materials from a manufacturing process based on ICH guideline. In these systems, all the processes from raw material to final finished product would be continuously produced. LÄS MER