Sökning: "Immunogenic Proteins"

Visar resultat 1 - 5 av 7 uppsatser innehållade orden Immunogenic Proteins.

  1. 1. Characterization of Antigenic Properties of Two Immunogenic Proteins of Streptococcus pneumoniae 

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Mawj Jasimalsalih; [2023]
    Nyckelord :Immunogenic Proteins; PrsA; MalX; Membrane Vesicles; Protein Properties; Streptococcus pneumoniae virulence factors;

    Sammanfattning : The bacterium Streptococcus pneumoniae (pneumococcus), is considered to be a leading cause of morbidity and mortality globally, particularly in infants and the elderly. It is one of the most frequent causes of respiratory tract infections, which sporadically have the potential to develop into serious invasive symptoms including sepsis and meningitis. LÄS MER

  3. 2. Hello P. pastoris! : The cultivatin and expression of proteins in the yeast Pichia pastoris

    Kandidat-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Håkansson Anja; Dalén Therese; Gröblacher Josefine; Göransson William; Jaksties Jonathan; Ortstad Nathalie; Lenkeit Gesser Pauline; [2022]
    Nyckelord :Affibody AB; Pichia pastoris; pAOX1; pAOX2; pFLD1; pGAP; cultivation; fermentation; glycosylation;

    Sammanfattning : Producing pharmaceuticals in Escherichia coli inevitably comes with an extensive purification process. This is because many of the native proteins of E. coli are immunogenic to humans, especially the heat and pH resistant endotoxins located in the membrane of E. coli. LÄS MER

  4. 3. Development of a reporter gene assay on an automated platform

    Master-uppsats, Lunds universitet/Beräkningskemi; Lunds universitet/Tillämpad biokemi

    Författare :Fanny Redin; [2021]
    Nyckelord :Reporter gene assay; Automation; Svar Life Science; Immunogenicity; TNF-alpha; Applied biochemistry; Technology and Engineering; Biology and Life Sciences;

    Sammanfattning : Biological drugs have the potential to trigger unwanted immunogenic responses in patients which might affect the efficacy and safety of the treatment. Evaluating the immunogenicity throughout the drug development process is therefore crucial. LÄS MER

  5. 4. Goodbye E.coli : Alternativa endotoxinfria produktionssystem till Escherichia coli

    Kandidat-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Jenny Eriksson; Sofia Fasth; Cecilia Orrenius; Plavsic Milica; Linnéa Yuan Andersson; Marcus Westholm; [2020]
    Nyckelord :;

    Sammanfattning : Affibody is interested in replacing Escherichia coli as the production system for Affibody®-molecules in order to reduce the amount of resources needed for the purification step. The aim of this report is to present relevant endotoxin-free alternatives that would suit production. LÄS MER

  7. 5. Induction of HPV-16 Late Gene Expression Through Use of Small Molecule Drugs

    Kandidat-uppsats, Uppsala universitet/Institutionen för kvinnors och barns hälsa

    Författare :Caroline Andrén; [2016]
    Nyckelord :Human papillomavirus type 16; Cervical cancer; Cell culture; TPA; CAT ELISA;

    Sammanfattning : Cervical cancer is the second most common cancer in women worldwide. The principal cause of cervical cancer is infection with human papillomavirus (HPV). HPV-16 is a high-risk virus and it is responsible for a high portion of all HPV-caused cancers. The HPV-16 genome consists of early and late genes. LÄS MER