Sökning: "Mdr1"

Visar resultat 1 - 5 av 8 uppsatser innehållade ordet Mdr1.

  1. 1. P-glykoprotein-mutationen - ABCB1-1Δ hos collies i Sverige

    Master-uppsats, SLU/Dept. of Anatomy, Physiology and Biochemistry

    Författare :Alice Gustafsson; [2024]
    Nyckelord :P-glykoprotein; ABCB1; ABCB1-1Δ; MDR1; collie;

    Sammanfattning : P-glykoprotein är ett effluxprotein som uttrycks på olika luminala ytor i flera organ, bland annat tarmväggen, njurtubuli, i leverns gallgångar samt i blodhjärnbarriären. Proteinet kodas av genen ABCB1 hos hund. LÄS MER

  3. 2. In silico and in vitro determination of substrate specificity for Breast Cancer Resistance Protein (BCRP) transporter at the blood-brain barrier

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Fen Wang; [2021]
    Nyckelord :BCRP; substrate specificity; BBB; ATP-binding cassette ABC transporter; Drug transport;

    Sammanfattning : Background The Breast Cancer Resistance Protein (BCRP) drug transporter is important for drug disposition and plays a critical role in regulating drug entry into the brain. Its substrate spectrum overlaps with substrates of Multi Drug Resistance Protein 1 (MDR1, P-gp), which influences and complicates the interpretation of data on drug distribution into tissues (e. LÄS MER

  4. 3. Models for predicting efflux transport over the blood-brain barrier

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Marjaneh Janani; [2020]
    Nyckelord :efflux transport; brain; blood-brain-barrier; Verapamil; Risperidone; Prazosin;

    Sammanfattning : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. LÄS MER

  5. 4. Models for predicting efflux transport over the blood-brain barrier

    Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Marjaneh Janani; [2020]
    Nyckelord :Efflux; blood-brain-barrier; modeling; transporter;

    Sammanfattning : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. LÄS MER

  7. 5. MDR1-mutationen hos hundar

    Kandidat-uppsats, SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Författare :Johanna Olsson; [2015]
    Nyckelord :P-glykoprotein; MDR1; mutation; hund; makrocykliska laktoner; P-glycoprotein; dog; macrocyclic lactones;

    Sammanfattning : P-glykoprotein (P-gp) är en effluxtransportör som ursprungligen uppmärksammades för sin kapacitet att skydda tumörceller från flertalet läkemedel. Det har sedan visat sig att P-gp även finns i andra vävnader, som tarm, njurtubuli, lever samt i hjärnans kapillära endotelceller. LÄS MER