Sökning: "Sequence Alignment"

Visar resultat 1 - 5 av 35 uppsatser innehållade orden Sequence Alignment.

  1. 1. Prediction of multiple conformational states of membrane proteins

    Master-uppsats, Linköpings universitet/Bioinformatik

    Författare :Tobias Thorén; [2024]
    Nyckelord :Bioinformatics; Protein prediction; AlphaFold;

    Sammanfattning : Predicting protein structures has long been an area of active research in the field ofbioinformatics. Great strides have recently been made in this area by googles DeepMindteam. They developed an AI called AlphaFold which is able to make the most accuratepredictions of protein structures as of date. LÄS MER

  3. 2. Determining Protein Conformational Ensembles by Combining Machine Learning and SAXS

    Master-uppsats, KTH/Tillämpad fysik

    Författare :Samuel Eriksson Lidbrink; [2023]
    Nyckelord :AlphaFold; AlphaFold2; SAXS; protein conformational ensembles; machine learning; protein conformations; reweighting; SAXS; AlphaFold; AlphaFold2; proteinkonformationsensembler; maskininlärning; proteinkonformationer; omviktning;

    Sammanfattning : In structural biology, immense effort has been put into discovering functionally relevant atomic resolution protein structures. Still, most experimental, computational and machine learning-based methods alone struggle to capture all the functionally relevant states of many proteins without very involved and system-specific techniques. LÄS MER

  4. 3. Predicting Protein Stability with Machine Learning

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Biofysikalisk kemi

    Författare :Lucas Carlsson; [2023]
    Nyckelord :Protein Stability; Biophysical Chemistry; Thermodynamics; Machine Learning; Deep Learning; Protein Language Model; Biochemistry; Multiple Sequence Alignment; Bioinformatics; Biology and Life Sciences;

    Sammanfattning : Protein stability is a property of high importance and is of interest in a variety of fields. It determines if a protein has its native fold and can be of influence in certain diseases such as Parkinson's and Alzheimer's disease. LÄS MER

  5. 4. Co-evolutional anaylsis of the Na+,K+-ATPase’s β-subunit dimerization

    Master-uppsats, KTH/Tillämpad fysik

    Författare :Sebastian Bauer; [2023]
    Nyckelord :Na ; K -ATPase NKA ; Co-evolution; Dimerization; Direct coupling analysis DCA ; Molecular dynamic MD simulation; Contact filtering; Mapping; Na ; K -ATPas NKA ; Samevolution; Dimerisering; Direkt kopplingsanalys DKA ; Molekylär dynamisk MD simulering; Kontaktfiltrering; Kartläggning;

    Sammanfattning : Does the active membrane transporter, Na+,K+-ATPase dimerize? If it does, whatis the functional benefit? Does it increase or decrease the turnover rate? Theseare still unanswered questions and current research topics. Previous studies havedemonstrated dimerizations in closely related proteins of the P-type ATPase family. LÄS MER

  7. 5. Implementation of an Irregular Packaging Algorithm for Multi-Container

    Master-uppsats, Uppsala universitet/Industriell teknik

    Författare :Azad Fakhir Salih; [2023]
    Nyckelord :irregular packaging problem; genetic algorithm; bottom-left placement; polygon-based geometric representation; proximity-based strategies;

    Sammanfattning : This study introduces an innovative approach to address a complex, real-world packing problem experienced at Emerson Rosemount Tank Radar. The objectives of the study are manifold: primarily, the optimization of packing efficiency within specified geometric and box constraints, and secondarily, the fulfillment of specific packing objectives. LÄS MER