Sökning: "antibody test"

Visar resultat 16 - 20 av 53 uppsatser innehållade orden antibody test.

  1. 16. Advanced control of chromatography systems for automated analysis of monoclonal antibodies

    Master-uppsats, Lunds universitet/Kemiteknik (CI)

    Författare :Jerry Guan; [2021]
    Nyckelord :Chemical engineering; Kemiteknik; Chromatography; Analysis; HPLC; Python; Automatic process control; Monoclonal Antibodies; Antibody purification; Technology and Engineering;

    Sammanfattning : Nedströmsprocesser för rening av biologiska läkemedel som monoklona antikroppar rör sig från batch-processer till kontinuerliga, och vidare till helt automatiska, kontinuerliga nedströmsprocsser. En del av visionen för automatiska reningsprocesser är möjligheten att automatiskt analysera från olika steg av reningen. LÄS MER

  3. 17. Affinity Based Capture of Circulating Tumour Cells Using Designed Ankyrin Repeat Proteins (DARPins) in a Microfluidic System

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Emil Spåre; [2021]
    Nyckelord :Designed ankyrin repeat proteins; DARPins; microfluidics; circulating tumour cells; affinity based cell capture; surface modification; Designade ankyrinupprepningsproteiner; DARPiner; mikrofluidik; cirkulerande tumörceller; affinitetsbaserad celluppfångst; ytförändring;

    Sammanfattning : Designade ankyrinupprepningsproteiner (DARPiner) är små, mycket stabila antikroppsmimetiska proteiner. I det här projektet användes anti-EpCAM-DARPiner tillsammans med mikrofluidik för att avgära om de kunde fånga upp HCT116-celler mer effektivt än anti-EpCAM-antikroppar. LÄS MER

  4. 18. Applying Model Selection on Ligand-Target Binding Kinetic Analysis

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Klara Djurberg; [2021]
    Nyckelord :LigandTracer; kinetic models; Rituximab; Bayesian inference; Bayesian model selection; LigandTracer; interaktionsmodeller; Rituximab; Bayesiansk inferens; modellval;

    Sammanfattning : The time-course of interaction formation or breaking can be studied using LigandTracer, and the data obtained from an experiment can be analyzed using a model of ligand-target binding kinetics. There are different kinetic models, and the choice of model is currently motivated by knowledge about the interaction, which is problematic when the knowledge about the interaction is unsatisfactory. LÄS MER

  5. 19. Determination of Mass- and Heat Transfer Coefficients for Computer Modelling of Pharmaceutical Freeze-Drying

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Linnea Gustafsson; [2021]
    Nyckelord :Freeze-drying; Mass- and Heat Transfer; Pharmaceutical production; Simulation; MATLAB; Pharmaceutical technology; Technology and Engineering;

    Sammanfattning : This thesis work deals with the determination of mass- and heat transfer coefficients for pharmaceutical vial freeze-drying and the one-dimensional steady state computer modelling of primary drying. The overall heat transfer coefficient K_V for the vial/freeze-dryer system was successfully determined using a gravimetric method. LÄS MER

  7. 20. Development of a reporter gene assay on an automated platform

    Master-uppsats, Lunds universitet/Beräkningskemi; Lunds universitet/Tillämpad biokemi

    Författare :Fanny Redin; [2021]
    Nyckelord :Reporter gene assay; Automation; Svar Life Science; Immunogenicity; TNF-alpha; Applied biochemistry; Technology and Engineering; Biology and Life Sciences;

    Sammanfattning : Biological drugs have the potential to trigger unwanted immunogenic responses in patients which might affect the efficacy and safety of the treatment. Evaluating the immunogenicity throughout the drug development process is therefore crucial. LÄS MER