Sökning: "cytotoxicity"

Visar resultat 11 - 15 av 42 uppsatser innehållade ordet cytotoxicity.

  1. 11. Development of a reporter gene assay on an automated platform

    Master-uppsats, Lunds universitet/Beräkningskemi; Lunds universitet/Tillämpad biokemi

    Författare :Fanny Redin; [2021]
    Nyckelord :Reporter gene assay; Automation; Svar Life Science; Immunogenicity; TNF-alpha; Applied biochemistry; Technology and Engineering; Biology and Life Sciences;

    Sammanfattning : Biological drugs have the potential to trigger unwanted immunogenic responses in patients which might affect the efficacy and safety of the treatment. Evaluating the immunogenicity throughout the drug development process is therefore crucial. LÄS MER

  3. 12. IL13R⍺2-CAR T cells for Immunotherapy of Glioblastoma

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Xu Zhu; [2021]
    Nyckelord :;

    Sammanfattning : Glioblastoma is the most malignant form of gliomas and is a highly infiltrative while non-metastatic tumor of the central nervous system. Patients with glioblastoma have a poor prognosis of 15 months median survival after diagnosis. LÄS MER

  4. 13. Ouabain Toxicity -Selectivity Towards Renal Cancer Cells

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Emma Magnusson; [2020]
    Nyckelord :Cardiotonic steroids; ouabain; Na K -ATPase; cytotoxicity; renal cancer; apoptosis; Kardiotoniska steroider; ouabain; Na K -ATPase; cytotoxicitet; njurcancer; apoptos;

    Sammanfattning : Ouabain and other cardiotonic steroids are known to inhibit Na + ,K + -ATPase (NKA), theion pump responsible for the ionic gradient across the plasma membrane. These steroidsdisplay a selective toxicity towards several tumour cells in comparison to primary humancells, however, the mechanism behind this is not yet understood. LÄS MER

  5. 14. The Influence of 3D Cell Organization in Tumor Spheroid on Natural Killer Cell Infiltration and Migration

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Luigi Morrone; [2020]
    Nyckelord :Natural Killer Cells; Tumor Spheroids; Fluorescence Microscopy; Infiltration; Migration; Killing;

    Sammanfattning : Natural Killer cells are a type of lymphocyte belonging to the innate immune system and they operate cell-mediated cytotoxicity and release of pro-inflammatory cytokines against cancerous cells. However, in vivo testings have shown a reduced activity of NK cells against solid tumors probably due to the negative influence of the immunosuppressive tumor microenvironment. LÄS MER

  7. 15. Evaluation of Potential Cytotoxic and Genotoxic Effects of Propolis in CHO-K1 Cells Using an in vitro Version of the Micronucleus Assay

    Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Elina Rosenborg; [2020]
    Nyckelord :propolis; micronucleus assay; genotoxicity; cytotoxicity; CHO-K1 cells; mitomycin C;

    Sammanfattning : Background Evaluating potential genotoxicity of pharmaceutical drug candidates is important during drug development. A method that can be used for this purpose is the micronucleus assay (MN- assay) which can identify agents that induce chromosomal damage. LÄS MER