Sökning: "galectin"

Visar resultat 1 - 5 av 11 uppsatser innehållade ordet galectin.

  1. 1. Exploring a unique pocket in Galectin-8N by the synthesis of D-galactoside-based benzimidazole inhibitors

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Sid Bartold; [2023]
    Nyckelord :organic chemistry; synthesis; gal; gal-8; gal-8N; galectin; galectin-8; galectin-8N; inhibitor; drug development; benzimidazole; galactoside; carbohydrate; carbohydrate chemistry; Suzuki-coupling; Chemistry;

    Sammanfattning : Galectins are a family of glycan-binding proteins where galectin-8 is a part of the subgroup known as tandem-repeat type galectins. Galectin-8 is composed of two homologous CRDs, one N- and one C-terminal CRD. As it stands now, galectin-8N has been found to bind to a larger number of glycans than galectin-8C. LÄS MER

  3. 2. Design, synthesis, and evaluation of 1-phenylethanol and C2 threitol derivatives as non-pyranose galactose-mimicking inhibitors of Galectin-3

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Qrystal Cruz Giron; [2023]
    Nyckelord :Galectin-3; Galectin-3 inhibitor; 1-phenylethanol; C2 threitol derivative; galactose-mimicking inhibitor; organic chemistry; Chemistry;

    Sammanfattning : Galectins are cytosolic protein family involved in several biological functions such as cell differentiation, cell migration and apoptosis amongst many others. Their presence is also substantial in diseases including acute inflammation, fibrosis, allergies, and cancer. LÄS MER

  4. 3. Crystallization, optimization, and crystal structure determination of ligands in complex with galectin-8N

    Kandidat-uppsats, Lunds universitet/Kemiska institutionen

    Författare :George Larsson; [2022]
    Nyckelord :Biochemistry; Structural Biochemistry; Galectin-8; Protein Crystallization; Chemistry;

    Sammanfattning : This thesis focuses on the protein “galectin-8N” which is a lectin protein that takes part in several physiological functions such as inflammation, autophagy, cell migration, and more. The project has three objectives: to observe and increase the reproducibility of crystallization of two variants (wildtype and mutant) of the human protein galectin-8N and to analyze the binding site when three different novel ligands are each inserted. LÄS MER

  5. 4. Design och syntes av potentiella inhibitorer för galektin-1

    Kandidat-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Victoria Ullbin; [2022]
    Nyckelord :galektin-1; inhibitor; galektin; cancer; organic chemistry; Chemistry;

    Sammanfattning : Galectin-1 is a member of the carbohydrate-binding protein family galectins. Galectins are involved in the immune system. However, in cancer growth, galectin-1 is overproduced to not make the immune system respond. Therefore, inhibitors of the protein were synthesized to make the immune system approach the cancer and respond. LÄS MER

  7. 5. The Effect of Using DMSO as a Cosolvent for Ligand Binding Studies

    Master-uppsats, Lunds universitet/Biofysikalisk kemi

    Författare :Simon Birgersson; [2019]
    Nyckelord :Galectins; Nuclear Magnetic Resonance; NMR; Biophysical Chemistry; Relaxation; CPMG; ITC; Biofysikalisk Kemi; Kärnmagnetisk resonans; Technology and Engineering; Chemistry; Biology and Life Sciences;

    Sammanfattning : DMSO sees common application as a solvent for studies of synthetic molecules in biological systems, in fields such as drug design. Despite this, the possibility and nature of solvent interactions with both synthetic ligand and their target macromolecules is widely unexamined. LÄS MER