Sökning: "x-ray crystallography"

Visar resultat 1 - 5 av 24 uppsatser innehållade orden x-ray crystallography.

1. 1. A Machine Learning Approach on Analysis of Emission Spectra for Application in XFEL Experiments

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för fysik och astronomi

   Författare :Harald Agelii; [2023]
   Nyckelord :Structural biology; Machine learning; Neural networks; emission spectrum; XFEL; X-ray free electron laser; SFX; Serial femtosecond X-ray crystallography; Proteins; Diagnostics;

   Sammanfattning : In this thesis we investigate two potential applications of machine learning in the context of X-ray imaging and spectroscopy of biological samples, particularly such using X-ray free electron lasers (XFEL). We first investigate the possibility of using an emission spectrum, recorded from a sample after being probed by an incident X-ray, as a diagnostic tool. LÄS MER

3. 2. Acoustic Focusing of Lysozyme Crystals

   Master-uppsats, KTH/Tillämpad fysik

   Författare :Måns Junestrand; [2023]
   Nyckelord :Protein Crystals; Lysozyme Crystals; Ultrasound; Acoustic Focusing; SFX; Biomedical Physics; Proteinkristaller; Ultraljud; Lysozymkristaller; Akustisk fokusering; SFX; Biomedicinsk fysik;

   Sammanfattning : Acoustic focusing of microscale protein crystals with acoustophoresis technology could reduce clogs during experiments with the scientific technique serial femtosecond x-ray crystallography (SFX). SFX determines molecular structures of proteins, these structures are valuable in drug discovery and fundamental biomedical research. LÄS MER

4. 3. Expression and purification of pyruvate transporting human mitochondrial pyruvate carrier (MPC) protein complex for structural studies

   Magister-uppsats, Lunds universitet/Examensarbeten i molekylärbiologi

   Författare :Markus Wendler; [2022]
   Nyckelord :Biology and Life Sciences;

   Sammanfattning : Pyruvate is one of the main molecules needed for the citric acid cycle, which produces energy in the form of ATP. The citric acid cycle reaction occurs in the mitochondrial matrix, and for pyruvate to participate in the reaction, it needs to be transported from the cytosol across the mitochondrial membranes into the mitochondrial matrix. LÄS MER

5. 4. Structure-based design of new antiviral substances against the Venezuelan equine encephalitis virus

   Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

   Författare :Elin Öberg; [2022]
   Nyckelord :x-ray crystallography; protein crystallization; Venezuelan equine encephalitis virus; structure-based drug design; applied biochemistry; Technology and Engineering;

   Sammanfattning : The Venezuelan equine encephalitis virus (VEEV) is a highly infectious alphavirus responsible for severe outbreaks and epidemics in the Americas. The nonstructural protein 2 (nsP2) cysteine protease plays a fundamental role in the VEEV replication process, and is therefore, an attractive drug target for structure-based drug design using x-ray crystallography. LÄS MER

7. 5. Investigation of the function of the SH3-like domain of the Saccharopolyspora erythraea iron-dependent regulator

   Master-uppsats, Uppsala universitet/Institutionen för kemi - BMC

   Författare :Carita Hammar; [2022]
   Nyckelord :;

   Sammanfattning : The bacterium Saccharopolyspora erythraea is utilized to produce the widely used antibiotic erythromycin. With the increasing problem of antibiotic resistance, the development of derivatives of the drug is of great importance. To produce antibiotics biosynthetically, it is crucial to understand the metabolic pathways utilized by the bacterium. LÄS MER