Sökning: "Affinity proteins"
Visar resultat 1 - 5 av 77 uppsatser innehållade orden Affinity proteins.
1. Design and Evaluation of Peptide Binders : In silico evaluation and comparison of generative AI for de novo peptide binder design
Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Beräkningsbiologi och bioinformatikSammanfattning : Peptide binders are short proteins that bind to larger proteins. Due to peptide binders having high specificity and being cheap to synthesize, they are a prime candidate for drug design. Creating new proteins in silico can be divided into three steps: protein backbone generation, sequence design, and computational filtering. LÄS MER
2. Characterization of Mitilysin Pores by Cryo-electron Microscopy
Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildningSammanfattning : Pore forming toxins (PFTs) are a large group of proteins found mainly in bacteria with some exceptions found in animals. They bind and form pores in their target membranes and form pores, which leads to cell death. Among these are cholesterol-dependent cytolysins (CDC), which require the presence of cholesterol to bind target membranes. LÄS MER
3. Exploring a unique pocket in Galectin-8N by the synthesis of D-galactoside-based benzimidazole inhibitors
Master-uppsats, Lunds universitet/Centrum för analys och syntesSammanfattning : Galectins are a family of glycan-binding proteins where galectin-8 is a part of the subgroup known as tandem-repeat type galectins. Galectin-8 is composed of two homologous CRDs, one N- and one C-terminal CRD. As it stands now, galectin-8N has been found to bind to a larger number of glycans than galectin-8C. LÄS MER
4. Generation of a new ADAPT library for stability improvement
Master-uppsats, KTH/ProteinvetenskapSammanfattning : Under senare år har målinriktad terapi varit ett växande område inom cancerterapi som en mer målinriktad behandling än kemoterapi. Dessa behandlingar baseras främst på antikroppsbaserade läkemedel som är ganska stora och komplexa, vilket ökar den totala kostnaden för behandlingen. LÄS MER
5. Characterization of potato protein and its calcium binding capacity
Master-uppsats, Lunds universitet/Beräkningskemi; Lunds universitet/Tillämpad biokemiSammanfattning : Calcium is essential for the human body as it has functions in the nervous system, bones and formation of teeth. Deficiency in this important nutrient can be detrimental to health and cause life-long issues. Calcium can be found in various foods, like dairy products, but certain plant-based alternatives to milk needs to be fortified with calcium. LÄS MER