Sökning: "Massively Parallel Library"
Hittade 5 uppsatser innehållade orden Massively Parallel Library.
1. Understanding sequence errors in analysis of short tandem repeats through optimisation of a library preparation protocol utilising unique molecular indices
Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildningSammanfattning : In the last few years massively parallel sequencing (MPS) has become important for forensic DNA analysis by providing new and broader possibilities, such as increased discrimination power for short tandem repeat (STR) analyses. An imperative part of MPS analysis is library preparation where there is a fundamental reliability on in vitro DNA polymerisation, which is prone to errors. LÄS MER
2. Optimisation of ForenSeq STR data analysis with FDSTools and comparative analysis with UAS
Master-uppsats, Högskolan i Skövde/Institutionen för biovetenskapSammanfattning : DNA profiling with short tandem repeat data generated with massively parallel sequencing is associated with several challenges. FDSTools is an open-source software which applies correction models based on a reference database to correct DNA profiles. LÄS MER
3. Library construction optimization and analysis of Short Tandem Repeats by a simple, PCR-based DNA barcoding method
Master-uppsats, Lunds universitet/Teknisk mikrobiologi; Lunds universitet/BioteknikSammanfattning : DNA profiling is evolving in the forensics community towards introducing massively parallel sequencing (MPS) as a complement to capillary electrophoresis (CE). Obstacles remain however before this technology can become routine in forensic casework, such as the development of more efficient bioinformatics solutions and recommendations concerning data analyses. LÄS MER
4. Modeling the intronic regulation of Alternative Splicing using Deep Convolutional Neural Nets
Master-uppsats, KTH/Skolan för datavetenskap och kommunikation (CSC)Sammanfattning : This paper investigates the use of deep Convolutional Neural Networks for modeling the intronic regulation of Alternative Splicing on the basis of DNA sequence. By training the CNN on massively parallel synthetic DNA libraries of Alternative 5'-splicing and Alternatively Skipped exon events, the model is capable of predicting the relative abundance of alternatively spliced mRNA isoforms on held-out library data to a very high accuracy (R2 = 0. LÄS MER
5. A next generation sequencing approach to constructing a genetic map for Populus tremula
Master-uppsats, SLU/Dept. of Forest Genetics and Plant PhysiologySammanfattning : Plant biologists have long been studying phenotypic and physiological variation and the molecular mechanisms underlying natural variation in these processes have stimulated scientists to uncover the genomic polymorphism responsible for such variation. Populus tremula, (European aspen, hereafter referred to as aspen), is a member of Populus genus, which has become a model system for genetic and genomic studies and, more recently, for studies linking genomics to ecology and evolution. LÄS MER