Sökning: "Population PK modeling"

Hittade 3 uppsatser innehållade orden Population PK modeling.

  1. 1. Populations PK-modellering för IR-formulering av Gliclazid

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Haneen Hussein; [2022]
    Nyckelord :Typ 2-diabetes; Gliclazid; Populations PK-modellering; Monolix;

    Sammanfattning : Introduction: Type-2 diabetes is one of the most common metabolic diseases characterized by elevated blood sugar levels in the body. The disease is caused by lost insulin sensitivity and insufficient insulin production, which leads to an increase in sugar levels in the blood. LÄS MER

  3. 2. Evaluation of Robust Model Building Tools to Improve the Efficiency of Non-linear Mixed Effect Model Building Workflows

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Karin Norgren; [2021]
    Nyckelord :Population PK modeling; Pharmacometrics; NLME modeling;

    Sammanfattning : Population PK models aim to describe the change in drug concentration over time for a specific population. The populations in population PK modelling often refer to subjects in a clinical trial of a potential drug candidate. LÄS MER

  4. 3. Individualization of fixed-dose combination regimens : Methodology and application to pediatric tuberculosis

    Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Gunnar Yngman; [2015]
    Nyckelord :pharmacometrics; pharmacokinetics; PK; population pharmacokinetics; optimal design; FDC; fixed-dose combination; pediatrics; tuberculosis; rifampicin; pyrazinamide; isoniazid; ethambutol; modeling; simulation; estimation; allometric scaling; stochastical simulation and estimation; NONMEM; MATLAB; FO; FOCE; Expectation-Maximization algorithm; importance sampling; Nelder-Mead method; logistic function; discontinuity; euclidean distance; Sammon mapping; global minimum; local minima;

    Sammanfattning : Introduction: No Fixed-Dose Combination (FDC) formulations currently exist for pediatric tuberculosis (TB) treatment. Earlier work implemented, in the software NONMEM, a rational method for optimizing design and individualization of pediatric anti-TB FDC formulations based on patient body weight, but issues with parameter estimation, dosage strata heterogeneity and representative pharmacokinetics remained. LÄS MER