Sökning: "Protein misfolding"
Hittade 5 uppsatser innehållade orden Protein misfolding.
1. Effect of DNAJB6 on α-synuclein amyloid fibril aggregation and dis-aggregation
Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Biofysikalisk kemiSammanfattning : Amyloid proteins are a group of proteins with the ability to form large fibrillar aggregates, identifiable by their cross-β core structure. These aggregates are linked to several different neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease and due to the growing rate of people diagnosed, there is a need to combat these diseases. LÄS MER
2. Competition between Phase Separation and Micellization in a Coarse-Grained Protein Model with Two Components
Master-uppsats, Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation; Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisationSammanfattning : Intrinsically disordered proteins (IDPs) are widely believed to play a key role in the for- mation of intracellular biomolecular condensates through liquid-liquid phase separation (LLPS). Furthermore, it has been shown in vitro that several IDPs are able to phase sepa- rate on their own. LÄS MER
3. Development of an antibioticsresistancebased method fordirected evolution of proteases
Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)Sammanfattning : Proteases have a fundamental role in regulating diverse biological processes and are important in the biotechnological and medical fields. Therapeutic proteases have great potential but have been limited due to the lack of high throughput protein engineering methods. LÄS MER
4. Synthesis of proteophenes that can be utilized as fluorescent ligands for biological targets
Master-uppsats, Linköpings universitet/KemiSammanfattning : Small fluorescent probes are important tools when studying protein aggregates involved in different neurodegenerative diseases, such as Alzheimer’s disease. Luminescent conjugated oligothiophenes have been developed and shown to be excellent ligands when studying morphology among amyloids, due to their conjugated thiophene backbone that provides them with unique photophysical properties. LÄS MER
5. Study of co-translational folding of E. coli dihydrofolate reductase using fluorescence resonance energy transfer (FRET)
Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildningSammanfattning : In prokaryotes, protein synthesis and folding are often coupled, and the protein begins to fold from the N-terminus as it is being synthesized. It has been hypothesised that there could be kinetic coupling of the speed of translation and the folding, which means that an altered rate of synthesis can cause a possible misfolding of the protein. LÄS MER