Kan supplementering med inulin eller oligofruktos minska aptiten hos personer med övervikt eller fetma?

Detta är en Kandidat-uppsats från Göteborgs universitet/Institutionen för medicin

Sammanfattning: AbstractTitle: Can Supplementation with Inulin or Oligofructose Decrease Appetite in Adults with Overweight or Obesity?- A Systematic ReviewAuthors: Johanna Aula and Ninni NilssonSupervisor: Sofia KlingbergExaminer: Klara SjögrenProgramme: Programme in dietetics, 180/240 ECTSType of paper: Bachelor’s thesis in clinical nutrition, 15 higher education creditsDate: May 25, 2021_________________________________________________________________________Background: Overweight and obesity is a serious public health problem. It is associated with premature death and several diseases. Common treatments are dietary therapy and bariatric surgery. The former often fails in long term effect; the latter is an invasive method with risk of complications. Dietary fibre can influence feelings of hunger and research in the area is being conducted in the hopes of finding components which can optimize dietary therapy. Objective: The aim of this systematic review was to evaluate the scientific evidence regarding whether supplementation with inulin or oligofructose can decrease appetite in adults with overweight or obesity.Search strategy: A literature search was conducted in PubMed and Scopus 2021-03-29. The search terms were: inulin, oligofructose, fullness, ”desire to eat”, “prospective consumption”, hunger, satiety, appetite, ”visual analogue scale”, supplement, obesity, overweight, blind, random, and also terms for varying terminology.Selection criteria: Inclusion criteria were randomized controlled trials conducted on adult participants with overweight or obesity published within the last ten years, where the intervention was supplementation with inulin or oligofructose and the control was placebo. Exclusion criteria were studies where the intervention was given in combination with another intervention or active ingredient, and studies not available in full text. Studies conducted on participants with specific diseases, as well as studies shorter than 24 hours, were also excluded. The outcomes were hunger, fullness, desire to eatand prospective consumption measured via VAS.Data collection and analysis:The literature search resulted in 54 articles. 20 duplicates were removed and the remaining 34 articles were reviewed by two independent reviewers, based on inclusion- and exclusion criteria. Finally, two articles were included. Risk of bias was measured using an audit template from SBU. The strength of the scientific evidence was evaluated according to GRADE.Main results: Three of the outcomes showed concordant results; neither of the studies showed a significant increase of fullness, while both studies showed a significant decrease of hunger and prospective consumption. Regarding desire to eat, the results were not concordant; there was a decrease in both studies, but only one of them was significant.Conclusions: The scientific evidence regarding whether supplementation with inulin or oligofructose can decrease appetite in adults with overweight or obesity is low (++).

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