Sökning: "Amyloid fibril"

Visar resultat 1 - 5 av 9 uppsatser innehållade orden Amyloid fibril.

  1. 1. Effect of DNAJB6 on α-synuclein amyloid fibril aggregation and dis-aggregation

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Biofysikalisk kemi

    Författare :Josef Getachew; [2023]
    Nyckelord :α-synuclein; alpha-synuclein; chaperones; DNAJB6; the unhappy chaperone; parkinsons disease; biophysical chemistry; biochemistry; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Sammanfattning : Amyloid proteins are a group of proteins with the ability to form large fibrillar aggregates, identifiable by their cross-β core structure. These aggregates are linked to several different neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease and due to the growing rate of people diagnosed, there is a need to combat these diseases. LÄS MER

  3. 2. Characterization of an unknown amyloid fibril protein

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Elin Persson; [2022]
    Nyckelord :;

    Sammanfattning : Amyloidosis is a group of diseases where misfolded proteins aggregate in the body. These aggregates are called amyloid and today there are 37 different known amyloid proteins. Diagnosis of amyloidosis is done by Congo Red staining to find amyloid, and typing with immunohistochemistry together with mass spectrometry. LÄS MER

  4. 3. Mechanical properties of films made of faba bean protein nanofiber and non-fibrillated protein

    Master-uppsats, SLU/Department of Molecular Sciences

    Författare :Alice Dunge; [2019]
    Nyckelord :Faba bean; amyloid; fibrils; meat substitutes; elasticity; stiffness; proteins;

    Sammanfattning : The production of livestock puts a huge strain on our ecosystem and the planet. It is the largest source of greenhouse gases and it causes loss in biodi-versity and pollution of water. One way to reduce these environmental dam-ages is to decrease the intake of meat and increase the intake of plant-based proteins. LÄS MER

  5. 4. Fluorescent fusion proteins as probes to characterize tau fibril polymorphism

    Master-uppsats, Linköpings universitet/Kemi

    Författare :Max Lindberg; [2019]
    Nyckelord :Alzheimer’s disease AD ; amyloids; FRET; tau; MAPT; fibrillation kinetics; seeding; fusion protein; EGFP; ECFP; EYFP; ThT; X-34; BTD14;

    Sammanfattning : Alzheimer's disease (AD) is a large and growing problem and while we today lack a full understanding of this disease, we know that the protein tau and the amyloid fibrils it forms play a central role in its development. We also know that these fibrils can have different morphologies in different diseases and that fibrils produced in vitro not necessarily adopt any of the morphologies found in patients. LÄS MER

  7. 5. Evaluating the Congo red staining method with the aim to solve problematics in the work process and optimize amyloidosis diagnostics

    Kandidat-uppsats, Uppsala universitet/Institutionen för kvinnors och barns hälsa

    Författare :Helena Östlund; [2017]
    Nyckelord :Polarization microscopy; Fluorescense; Optical properties; Amyloid fibril; binding mechanism.;

    Sammanfattning : Some diagnostic methods have been used for a very long time. Congo red stain saw the light of day in 1883, and quickly became important in many fields of use. Nowadays we recognize the importance of Congo red in diagnose of amyloid diseases. LÄS MER