Sökning: "In silico"

Visar resultat 1 - 5 av 67 uppsatser innehållade orden In silico.

  1. 1. A computational model of metapopulation dynamics and organism-mediated nutrient flow

    Master-uppsats, Göteborgs universitet / Institutionen för biologi och miljövetenskap

    Författare :Amanda Hansson; [2023-08-07]
    Nyckelord :computational model; population dynamics; metapopulation dynamics; nutrient flow; simulation; spatially explicit; individual-based;

    Sammanfattning : The aim of this project was to assess, using in-silico experiments, how different life history char-acteristics, such as age at maturity and dispersal ability of individuals, influence the dynamics of a metapopulation. To achieve this, a novel model of a spatially explicit metapopulation, with organ-ism-mediated nutrient flow between fragmented habitat patches, was implemented by means of computer simulations. LÄS MER

  3. 2. Design and Evaluation of Peptide Binders : In silico evaluation and comparison of generative AI for de novo peptide binder design

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Beräkningsbiologi och bioinformatik

    Författare :Linde Brokmar; [2023]
    Nyckelord :Protein design; de novo design; protein engineering; generative ai; machine learning; peptide binders; AF2; EvoBind; RFdiffusion; ProteinMPNN;

    Sammanfattning : Peptide binders are short proteins that bind to larger proteins. Due to peptide binders having high specificity and being cheap to synthesize, they are a prime candidate for drug design. Creating new proteins in silico can be divided into three steps: protein backbone generation, sequence design, and computational filtering. LÄS MER

  4. 3. Generalized super-resolution of 4D Flow MRI : extending capabilities using ensemble learning

    Master-uppsats, Linköpings universitet/Institutionen för medicinsk teknik

    Författare :Adam Hjalmarsson; Leon Ericsson; [2023]
    Nyckelord :4D Flow MRI; Ensemble learning; Super-resolution; Machine learning; Neural networks; 4DFlowNet;

    Sammanfattning : 4D Flow Magnet Resonance Imaging (4D Flow MRI) is a novel non-invasive technique for imaging of cardiovascular blood flow. However, when utilized as a stand-alone analysis method, 4D Flow MRI has certain limitations including limited spatial resolution and noise artefacts, motivating the application of dedicated post-processing tools. LÄS MER

  5. 4. Single-cell RNA-seq mapping of chicken leukocytes : An investigation into single-cell transcriptomics as an alternative to traditional immunological methods within non-traditional model organisms

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Mikrobiologi och immunologi

    Författare :Matilda Maxwell; [2023]
    Nyckelord :Bioinformatics; scRNA-seq; avian; immunology; Seurat; leukocytes; chicken; gallus gallus; 10x genomics; PCA;

    Sammanfattning : The immune system is a complex infrastructure where many cells interact with each other and perform duties depending on their type and function. When using traditional immunological methods in studying non-traditional model organisms, such as birds, challenges arise. LÄS MER

  7. 5. Integration of Deep Brain Stimulation Modeling Tools

    Master-uppsats, Uppsala universitet/Institutionen för informationsteknologi

    Författare :Lina Wilhelmina Sundqvist; [2023]
    Nyckelord :;

    Sammanfattning : Deep brain stimulation is a treatment in which neural targets are stimulated by electrical pulses delivered through implanted leads to alleviate symptoms in certain neurological- and psychiatric disorders. To achieve a beneficial clinical outcome, adjusting the stimulation parameters is a crucial step, which, at present, is a tedious and difficult trial-and-error procedure. LÄS MER