Sökning: "Dynamisk ljusspridning"

Visar resultat 1 - 5 av 6 uppsatser innehållade orden Dynamisk ljusspridning.

  1. 1. Methods to study device induced aggregation of proteins

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Marie Therese von Wowern; [2023]
    Nyckelord :protein formulation; protein aggregation; insulin; silicone oil; syringe; shear stress; subvisible particle; size exclusion chromatography; flow imaging microscopy; pharmaceutical technology; Technology and Engineering;

    Sammanfattning : This work developed a method for the investigation of how medical devices, such as syringes and needles, affect the formation of subvisible particles in a protein drug without excipients. Protein-based pharmaceuticals are well known to be sensitive to different kinds of stress, and exposure to stress during the use of this device is unavoidable. LÄS MER

  3. 2. Optimising microfluidic preparation of lipid sponge phase nanoparticles for biomolecule encapsulation

    Master-uppsats, Lunds universitet/Kemiteknik (CI)

    Författare :Owais Khalil; [2023]
    Nyckelord :Sponge phase; lipid nanoparticles; microfluidics; SAXS; cryo-TEM; DLS; chemical engineering; Chemistry;

    Sammanfattning : Drug delivery with lipid nanoparticles, especially sponge phase lipid nanoparticles (LNP), has been well studied because of its ability for drug encapsulation and transferring the drug through the cell membrane. The sponge phase LNP formulation could be affected by the molecular structure of the lipid, the temperature, pH, dilution, the buffer, and the addition of a stabiliser. LÄS MER

  4. 3. Solubility of Wood Xylans, Effect of pH and Concentration

    Master-uppsats, KTH/Glykovetenskap

    Författare :James Carlsson; [2022]
    Nyckelord :Xylan; Wood; Solubility; Dynamic Light Scattering; Filtration; Xylan; Trä; Löslighet; Dynamisk ljusspridning; Filtrering;

    Sammanfattning : Lösligheten av xylaner utvunna från trä undersöktes med Dynamisk Ljusspridning i syfte att observera eventuella förändringar i hydrodynamisk volym och ζ-potential. Xylaner extraherade från bok, björk och gran användes, där alkalisk extraherad bok erhölls kommersiellt och prover från björk och gran extraherades i förhand med subkritiskt vatten och alkalisk extraktion. LÄS MER

  5. 4. Självaggregering i blandningar av gallsalteroch fosfolipid undersöktes med statiskoch dynamisk ljusspridning vid 21 ̊ C och 37 ̊ C

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Robabeh Kheirkhah Abkenar; [2021]
    Nyckelord :NaC; natrium cholat; NaDC; natriumdeocykolat; DMPG; anjonic lipid dimyristoyl fosfatidylglycerol;

    Sammanfattning : Introduction: Phospholipids amphiphilic structure gives them special properties such as self-aggregation, emulsifying and wetting properties. Among the various structures resulting from the dissolution of phospholipids in water are the liposome, which acts as a drug carrier. LÄS MER

  7. 5. A comparison of different orthogonal techniques for the investigation of the conformational stability of NIST mAb in liquid formulations

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Madeleine Andersson; [2020]
    Nyckelord :Pharmaceutical technology; Läkemedelsteknologi; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Sammanfattning : A great challenge during early development of medicinal antibodies is to determine the stability of the candidates. This is required to be able to select the candidates with the greatest developability. LÄS MER