Sökning: "MedDRA"

Hittade 4 uppsatser innehållade ordet MedDRA.

  1. 1. Creation of a Next-Generation Standardized Drug Groupingfor QT Prolonging Reactions using Machine Learning Techniques

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Avdelningen för systemteknik

    Författare :Jacob Tiensuu; Elsa Rådahl; [2021]
    Nyckelord :Pharmacovigilance; Adverse Drug Reactions; MedDRA; VigiBase; WHODrug Global; QT prolongation; Torsades de Pointes; Individual Case Safety Reports; Text Recognition; Standardised Drug Grouping; Multinomial Logistic Regression; BERT;

    Sammanfattning : This project aims to support pharmacovigilance, the science and activities relating to drug-safety and prevention of adverse drug reactions (ADRs). We focus on a specific ADR called QT prolongation, a serious reaction affecting the heartbeat. Our main goal is to group medicinal ingredients that might cause QT prolongation. LÄS MER

  3. 2. Extracting Adverse Drug Reactions from Product Labels using Deep Learning and Natural Language Processing

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Shachi Bista; [2020]
    Nyckelord :;

    Sammanfattning : Pharamacovigilance relates to activities involving drug safety monitoring in the post-marketing phase of the drug development life-cycle. Despite rigorous trials and experiments that drugs undergo before they are available in the market, they can still cause previously unobserved side-effects (also known as adverse events) due to drug–drug interaction, genetic, physiological or demographic reasons. LÄS MER

  4. 3. Mapping medical expressions to MedDRA using Natural Language Processing

    Master-uppsats, Uppsala universitet/Institutionen för informationsteknologi

    Författare :Vanja Wallner; [2020]
    Nyckelord :Classification; Machine Learning; ML; Natural Language Processing; NLP; BERT;

    Sammanfattning : Pharmacovigilance, also referred to as drug safety, is an important science for identifying risks related to medicine intake. Side effects of medicine can be caused by for example interactions, high dosage and misuse. In order to find patterns in what causes the unwanted effects, information needs to be gathered and mapped to predefined terms. LÄS MER

  5. 4. Implementation and evaluation of a text extraction tool for adverse drug reaction information

    Magister-uppsats, Institutionen för biologisk grundutbildning

    Författare :Gunnar Dahlberg; [2010]
    Nyckelord :text extraction; adverse drug reactions; permutation; soundex; porter stemming; levenshtein distance; longest common subsequence distance;

    Sammanfattning : Inom ramen för Världshälsoorganisationens (WHO:s) internationella biverkningsprogram rapporterar sjukvårdspersonal och patienter misstänkta läkemedelsbiverkningar i form av spontana biverkningsrapporter som via nationella myndigheter skickas till Uppsala Monitoring Centre (UMC). Hos UMC lagras rapporterna i VigiBase, WHO:s biverkningsdatabas. LÄS MER