Sökning: "Preparative chromatography"

Visar resultat 1 - 5 av 9 uppsatser innehållade orden Preparative chromatography.

1. 1. Orbit-simulator for downstream processes

   Master-uppsats, Lunds universitet/Kemiteknik (CI)

   Författare :Andreas Malmström; [2022]
   Nyckelord :Chemical engineering; Process simulation; Downstream processes; Orbit; Preparative chromatography; Python; Lumped Rate Models; Technology and Engineering;

   Sammanfattning : In an ever more digitilized society, the transition is palpable also in the pharmaceutical industry. The control system Orbit was developed at the department of chemical engineering at Lund University, to be able to automate downstream processes based on the ÄKTA-system. LÄS MER

3. 2. Developing complementary supercritical fluid chromatographic methods for a high throughput purification process

   Master-uppsats, Karlstads universitet

   Författare :Alma Söderström; [2022]
   Nyckelord :Supercritical Fluid Chromatography; Pharmaceutical Industry; Column screening; Green chemistry; Superkritisk vätskekromotografi; Läkemedelsindustri; Kolonn set; Grön kemi;

   Sammanfattning : Supercritical fluid chromatography (SFC) is an expanding chromatographic technique that is part of the evolving field of green chemistry due to its short run times and use of non-toxic solvents in combination with recycled CO2. The use of a suitable column is essential for separation science in general and there is a wide variety of SFC compatible columns available on the market. LÄS MER

4. 3. Preparative chromatographyfor modified oligonucleotides : Method development for modified oligonucleotides, fromanalytical to preparative chromatography

   Master-uppsats, Karlstads universitet

   Författare :Rebecka Jasinski; [2021]
   Nyckelord :oligonucleotides; preparative chromatography; scaling-up; ion-pair chromatography; dibutylamine; oligonukleotider; preparativ kromatografi; uppskalning; jonparskromatografi; dibutylamin;

   Sammanfattning : Synthetic oligonucleotides, which are short strings of DNA or RNA, are a grooving area of importance for the pharmaceutical industry and for companies that manufacture diagnostic components. The manufacturing process of synthetic oligonucleotides involves many complex processes that use separation and purification techniques like ion-exchange chromatography, ion-pair reversed phase chromatography and ultra-performance liquid chromatography. LÄS MER

5. 4. The impact of various chromatographic conditions on the separation of modified and unmodified oligonucleotides

   Kandidat-uppsats, Karlstads universitet

   Författare :Lewis Frazer; [2021]
   Nyckelord :Oligonucleotide; Modified oligonucleotides; Ion-pair chromatography; Chromatography; Analytical chemistry; TEAA; DBA; Chemistry; Oligonukleotid; Modifierade oligonukleotider; Jonpars kromatografi; Kromatografi; Analytisk kemi; TEAA; DBA; Kemi;

   Sammanfattning : In this study, the effects of certain chromatographic conditions on various modified and unmodified oligonucleotides were investigated. At the forefront of this study was the investigation of a new Ion-pair Reversed-phase liquid chromatography (IP-RPLC) method, that had the potential to replace a previously established triethylammonium acetate (TEAA) IP-RPLC method developed for oligonucleotide separations. LÄS MER

7. 5. Iterative Learning Control for Preparative Chromatography

   Master-uppsats, Lunds universitet/Kemiteknik (CI)

   Författare :Daniel Espinoza; [2020]
   Nyckelord :Chemical Engineering; Kemiteknik; Chromatography; Automatic Process Control; Iterative Learning Control; ILC; Simulation; Protein Purification; Python; Ion-Exchange; Automation; Batch Processing; Downstream Processing; Technology and Engineering;

   Sammanfattning : There is a desire for a fully automated downstream process in pharmaceutical protein production. One part of the downstreaming process is preparative chromatography. A good separation between the product and other proteins, as well as good productivity, are desired. LÄS MER