Sökning: "compound 19"

Visar resultat 1 - 5 av 22 uppsatser innehållade orden compound 19.

  1. 1. Structural analysis of HZO thin film and electrode using X-ray diffraction

    Kandidat-uppsats, Lunds universitet/Synkrotronljusfysik; Lunds universitet/Fysiska institutionen

    Författare :Elliot Winsnes; [2024]
    Nyckelord :HZO; hafnia; hafnium dioxide; zirconium dioxide; ferroelectricity; ferroelectric; synchrotron radiation; X-ray diffraction; Physics and Astronomy;

    Sammanfattning : Since its discovery in 2011, the ferroelectricity of thin films based on HfO2 has been studied intensively. In particular, thin films with a 1:1 ratio of HfO2 and ZrO2 (HZO) has been of great interest. The ferroelectricity arises from a non-centrosymmetric orthorhombic (o) phase of HZO whose prevalence is dependent on the processing conditions. LÄS MER

  3. 2. Studies of broad-spectrum inhibitors against main protease of SARS-CoV-2 and other Coronaviruses

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Alexandra Stanciu; [2023]
    Nyckelord :human coronavirus 229E; SARS-CoV-2; main protease; nirmatrelvir; GC-376; compound 19;

    Sammanfattning : Coronaviruses have caused three large outbreaks in the past century. The most recent one, also still ongoing, is represented by the SARS-CoV-2/Covid-19 pandemic. Efforts have been taken to develop efficient vaccines and antivirals and one of the major virus-based targets in drug development is represented by the main protease of these viruses. LÄS MER

  4. 3. Intersecting Graph Representation Learning and Cell Profiling : A Novel Approach to Analyzing Complex Biomedical Data

    Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Nima Chamyani; [2023]
    Nyckelord :Graph representation learning; Cell profiling; Biological systems; Network medicine; Graphs; Machine learning techniques; Graph neural networks GNNs ; Protein-Compound-Pathway interactions; Biomarkers; Drug discovery;

    Sammanfattning : In recent biomedical research, graph representation learning and cell profiling techniques have emerged as transformative tools for analyzing high-dimensional biological data. The integration of these methods, as investigated in this study, has facilitated an enhanced understanding of complex biological systems, consequently improving drug discovery. LÄS MER

  5. 4. Predicting morphological effect of compounds on COVID-19 infected cells

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Läkemedelsdesign och läkemedelsutveckling

    Författare :Viktor Öhrner; [2023]
    Nyckelord :QSAR; ML; AI; bioinformatics; COVID-19; morphological profiles;

    Sammanfattning : The cost of developing new drugs is high and the aim of computer-assisted drug discovery is to reduce that development cost, either through virtual screening or generating novel compounds. System biology is one approach to drug discovery where the response of a biological system is the subject of study, instead of drug target interaction. LÄS MER

  7. 5. Phenotype and function of imiquimod-treated MUTZ-3 derived Langerhans cells in potential psoriatic 3D skin model

    Master-uppsats, Malmö universitet/Institutionen för biomedicinsk vetenskap (BMV)

    Författare :Emilie Allentoft Schousboe; [2023]
    Nyckelord :3D models; imiquimod; Langerhans cells; MUTZ-3 cell line; pro-inflammatory cytokines; psoriasis;

    Sammanfattning : Upon encounter of an antigen, epidermis-resident Langerhans cells (LCs) become activated and present the processed antigen to T cells of the draining lymph nodes, resulting in tolerogenic or inflammatory responses. In psoriasis plaques, skin homeostasis is disrupted and replaced by an inflammatory dermatitis. LÄS MER