Sökning: "Neurodegenerative disease"

Visar resultat 1 - 5 av 86 uppsatser innehållade orden Neurodegenerative disease.

  1. 1. ARIA-E vid behandling av Alzheimers sjukdom med monoklonala antikroppar

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Anna Hall; [2023]
    Nyckelord :Alzheimers sjukdom; aducanumab; lecanemab; gantanerumab; donanemab; ARIA-E; Apolipoprotein E4 ApoE4 ; cerebral amyloid angiopathy CAA ; screening; amyloid beta; monoklonala antikroppar;

    Sammanfattning : Introduction: Alzheimer's disease is a neurodegenerative disease that initially manifests itself primarily as impaired short-term memory and impaired language ability. The course of the disease is mainly due to an atrophy in the brain that can be attributed to the protein amyloid B and tau. LÄS MER

  3. 2. Speech Classification using Acoustic embedding and Large Language Models Applied on Alzheimer’s Disease Prediction Task

    Master-uppsats, KTH/Skolan för elektroteknik och datavetenskap (EECS)

    Författare :Maryam Kheirkhahzadeh; [2023]
    Nyckelord :Speech classification; Alzheimer’s disease detection; GPT-3; BERT; Text embedding; Dementia; wav2vec2.0; Klassificering av tal; detektion av Alzheimer’s sjukdom; GPT-3; BERT; textinbäddning; demens; wav2vec2.0;

    Sammanfattning : Alzheimer’s sjukdom är en neurodegenerativ sjukdom som leder till demens. Den kan börja tyst i de tidiga stadierna och fortsätta under åren till en allvarlig och obotlig fas. Språkstörningar uppstår ofta som ett av de tidiga symptomen och kan till slut leda till fullständig mutism i de avancerade stadierna av sjukdomen. LÄS MER

  4. 3. Neuropsychiatric Symptoms in Alzheimer's Disease: Associations with Beta Amyloid and Potential New Cutoff Points on Neuropsychiatric Assessment Scales

    Master-uppsats, Lunds universitet/Institutionen för psykologi

    Författare :David Christopher Wimmer; [2023]
    Nyckelord :Alzheimer s disease; dementia; neuropsychiatric symptoms; apathy; cognitively healthy; cognitively impaired; ROC analysis; Social Sciences;

    Sammanfattning : Neuropsychiatric Symptoms (NPS) have been shown to be associated with Alzheimer's disease ( AD). They negatively affect disease outcome and could play a future role in the detection of prospective AD cases. LÄS MER

  5. 4. Detection and quantification of post-translational modifications in non-invasive samples : Phosphoproteins as biomarkers and a market analysis of protein quantification technologies

    Kandidat-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Sammi Baudin; Hillevi Fjellström; Aron Kraft; Erica Lamberg; Måns Rosenbaum; Hanna Sjöstrand; [2023]
    Nyckelord :Phorphorylation; Proteomics; Biomarkers; Phosphoproteins; PTM; Amyotrophic lateral sclerosis; ALS; Alzheimer s disease; Parkinson s disease; Cancer; xMAP; SIMOA; NULISA; PEA; ELISA; Mass spectrometry; SomaScan;

    Sammanfattning : Post-translational modifications (PTMs) of proteins can be a sign and/or cause of disease. These modified proteins have the potential to be used as biomarkers for diagnostic purposes. However, research in the field is limited. LÄS MER

  7. 5. Effect of DNAJB6 on α-synuclein amyloid fibril aggregation and dis-aggregation

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Biofysikalisk kemi

    Författare :Josef Getachew; [2023]
    Nyckelord :α-synuclein; alpha-synuclein; chaperones; DNAJB6; the unhappy chaperone; parkinsons disease; biophysical chemistry; biochemistry; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Sammanfattning : Amyloid proteins are a group of proteins with the ability to form large fibrillar aggregates, identifiable by their cross-β core structure. These aggregates are linked to several different neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease and due to the growing rate of people diagnosed, there is a need to combat these diseases. LÄS MER