Sökning: "drug screening"
Visar resultat 6 - 10 av 63 uppsatser innehållade orden drug screening.
6. The impact of addition of force control agent in adhesive mixtures : Effect of magnesium stearates on flowability and aerosolization properties
Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaceutisk biovetenskapSammanfattning : When drugs need to be delivered to the respiratory system dry powder inhalers (DPIs) are often used. The powders in DPIs often consists of a micronized active pharmaceutical ingredient (API) that is adhered to a larger carrier particle forming an adhesive mixture. LÄS MER
7. Compounds screening for the identification of novel drug to improve the Knock in efficiency mediated by CRISPR-Cas9
Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildningSammanfattning : Genome editing is an exciting field that allows for the precise modification of an organism's DNA. One of the most advanced tools in this area is CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9), which creates a DSB (Double-strand break) at a specific location in the genome. LÄS MER
8. Phenotypic profiling and drug screening in Rhabdomyosarcoma cell lines
Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskapSammanfattning : Rhabdomyosarcoma (RMS) is a type of soft tissue sarcoma that mainly occurs in children. RMS can be divided into two subtypes embryonal (ERMS) and alveolar (ARMS). The ARMS subtype can be especially aggressive when a balanced chromosomal translocation is present. LÄS MER
9. Optimizing the Production of Aurora Kinase A and Validation of Constructs with different Sequential Lengths
Master-uppsats, Linköpings universitet/KemiSammanfattning : Aurora Kinase A is a kinase involved in multiple signaling pathways and interactions during mitosis, making it an essential kinase that deregulated causes cancer diseases in affected patients. Structural research shows mainly static snapshots of possible conformations of the partly disordered protein. LÄS MER
10. Developing and validating assay-ready HEK-Blue CD40L cells : For a more flexible and faster screening of Affibody® molecules
Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaceutisk biovetenskapSammanfattning : Cell assay that evaluates a biologics’ potency and efficacy is an important part in the discovery and development of drug candidates. However, it requires regular maintenance of cell cultures, and the cell assays can only be performed when the cells have reached 70-80% confluency. LÄS MER
