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Visar resultat 1 - 5 av 13 uppsatser som matchar ovanstående sökkriterier.

  1. 1. Predicting Protein Stability with Machine Learning

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Biofysikalisk kemi

    Författare :Lucas Carlsson; [2023]
    Nyckelord :Protein Stability; Biophysical Chemistry; Thermodynamics; Machine Learning; Deep Learning; Protein Language Model; Biochemistry; Multiple Sequence Alignment; Bioinformatics; Biology and Life Sciences;

    Sammanfattning : Protein stability is a property of high importance and is of interest in a variety of fields. It determines if a protein has its native fold and can be of influence in certain diseases such as Parkinson's and Alzheimer's disease. LÄS MER

  3. 2. Effect of DNAJB6 on α-synuclein amyloid fibril aggregation and dis-aggregation

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Biofysikalisk kemi

    Författare :Josef Getachew; [2023]
    Nyckelord :α-synuclein; alpha-synuclein; chaperones; DNAJB6; the unhappy chaperone; parkinsons disease; biophysical chemistry; biochemistry; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Sammanfattning : Amyloid proteins are a group of proteins with the ability to form large fibrillar aggregates, identifiable by their cross-β core structure. These aggregates are linked to several different neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease and due to the growing rate of people diagnosed, there is a need to combat these diseases. LÄS MER

  4. 3. Aromatic Ring Flips and Local Volume Fluctuations in BPTI

    Master-uppsats, Lunds universitet/Biofysikalisk kemi

    Författare :Simon Enbom; [2022]
    Nyckelord :Biophysical Chemistry; Molecular Dynamics; Protein Dynamics; Activation Volume; Aromatic Ring Flips; BPTI; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Sammanfattning : Aromatic ring flips are a classic example of a dynamic process in proteins. Discovered decades ago, methodological limitations hindered progress at the time. Ring flips have gained new interest and experimentalists can measure the flip rate and thermodynamic quantities associated with it. LÄS MER

  5. 4. Evaluating a coarse-grained IDP-model for structure and dynamics

    Kandidat-uppsats, Lunds universitet/Biofysikalisk kemi

    Författare :Louise Kalander; [2021]
    Nyckelord :IDP; Intrinsically disordered proteins; Histatin 5; Simulation; Biophysical chemistry; Chemistry;

    Sammanfattning : In this study a coarse-grained model of intrinsically disordered proteins (IDPs) is evaluated to determine whether the model is suitable to use for analyzing the structure and dynamics of IDPs. IDPs are proteins that lack a stable tertiary structure which gives them a flexible structure. LÄS MER

  7. 5. Towards Ca2+ Responsive Reticular Materials. An Evaluation of Suitable Conditions for Self-Assembly of the Protein S100G

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Biofysikalisk kemi

    Författare :Andreas Carlsson; [2021]
    Nyckelord :protein material; domain swapping; EF-hand; calbindin D9k; Ca2 dependent; aggregation; S100G; protein design; biophysical chemistry; Biology and Life Sciences;

    Sammanfattning : Att bygga material av proteiner är en konst som våra kroppar är specialister på. Men när vi medvetet försöker designa proteinmaterial, så blir det tydligt hur komplexa och svårstyrda biofysikens lagar är. LÄS MER