Sökning: "Strong Mutation"

Visar resultat 1 - 5 av 13 uppsatser innehållade orden Strong Mutation.

  1. 1. Effect of the cell-growth rate on the invasion and infection efficacy of Trypanosoma cruzi trypomastigotes, and the potential cell-to-cell transfer of the parasite

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Elisa Escabia Herrando; [2022]
    Nyckelord :Trypanosoma cruzi; infection kinetics; cell-to-cell infection; cell-growth rate;

    Sammanfattning : Recent studies proposed that mammalian cell lines with slower growth rates were infected more efficiently by Trypanosoma cruzi, and that cell-to-cell transmission could be occurring during infection. This open the question of whether host cell-growth rate is a cellular characteristic influencing Trypanosoma cruzi invasion and infection. LÄS MER

  3. 2. Development and validation of a novel quantitative PCR analysis method for HIV-1

    Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Författare :Josefine Sundgren; [2020]
    Nyckelord :HIV-1; qPCR; Octapharma; Taqman; applied biochemistry; tillämpad biokemi; Technology and Engineering;

    Sammanfattning : The major problem when developing primers and probe sets for detection of HIV-1 is its high genetic variability and strong ability to mutate. HIV-1 is divided into four groups, M, N, O, P based on genetic similarities, and there are more than 70 different circulating recombinant forms. LÄS MER

  4. 3. A pipeline for the identification and examination of proteins implicated in frontotemporal dementia

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Katharina Waury; [2020]
    Nyckelord :Bioinformatics; Proteomics; Dementia; FTD; Biomarker; Machine Learning; Random Forest; R; Pipeline;

    Sammanfattning : Frontotemporal dementia is a neurodegenerative disorder with high heterogeneity on the genetic, pathological and clinical level. The familial form of the disease is mainly caused by pathogenic variants of three genes: C9orf72, MAPT and GRN. LÄS MER

  5. 4. Protecting Privacy: Automatic Compression and Encryption of Next-Generation Sequencing Alignment Data

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Experimentell och klinisk onkologi

    Författare :Wiktor Gustafsson; [2019]
    Nyckelord :data protection; compression; encryption; genomic data; privacy; cancer; ngs; next-generation sequencing; AES; Zstandard; sequencing;

    Sammanfattning : As the field of next-generation sequencing (NGS) matures and the technology grows more advanced, it is becoming an increasingly strong tool for solving various biological problems. Harvesting and analysing the full genomic sequence of an individual and comparing it to a reference genome can unravel information about detrimental mutations, in particular ones that give rise to diseases such as cancer. LÄS MER

  7. 5. The role of odor receptor protein Or22a in Drosophila melanogaster oviposition and the response spectra of chimeric receptor protein Or22a-b

    Kandidat-uppsats, Lunds universitet/Examensarbeten i molekylärbiologi

    Författare :Lovisa Pettersson; [2018]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : The fruit fly Drosophila melanogaster has a well-studied olfactory system. A crucial part of the olfactory system is the olfactory sensory neurons (OSNs). One type of these OSNs, Ab3a, expresses the Odor receptors (ORs) Or22a and Or22b. LÄS MER