Sökning: "variant call format"

Hittade 2 uppsatser innehållade orden variant call format.

  1. 1. Demography of Birch Populations across Scandinavia

    Master-uppsats, Uppsala universitet/Växtekologi och evolution; Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Janek Sendrowski; [2022]
    Nyckelord :birch; betula; pubescens; pendula; betula pubescens; betula pendula; silver birch; downy birch; demography; population structure; distribution of fitness effects; DFE; dadi; UMAP; PCA; ADMIXTURE; polyDFE; ice age; glaciation; tree; boreal forest; climate change; adaption; tetraploid; diploid-tetraploid introgression; Scandinavia; genetic cluster; pipeline; snakemake; bioinformatics; reproducible; population genetics; postglacial population expansion; demographic history; FEEMS; site-frequency spectrum; SFS; last glacial maximum; LGM; workflow; python; population expansion; population growth; EST-SFS; 0-fold degenerate; 4-fold degenerate; maximum likelihood estimation; MLE; variant call format; VCF; single-nucleotide polymorphism; SNP;

    Sammanfattning : Boreal forests are particularly vulnerable to climate change, experiencing a much more drastic increase in temperatures and having a limited amount of more northern refugia. The trees making up these vast and important ecosystems already had to adapt previously to environmental pressures brought about by the repeated glaciations during past ice ages. LÄS MER

  3. 2. Identification of novel loss of heterozygosity collateral lethality genes for potential applications in cancer

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Margus Veanes; [2021]
    Nyckelord :biology; oncology; structural; genetics; bioinformatics; cancer;

    Sammanfattning : Over the course of this project, I demonstrate the utility of a 4-phase analysis pipeline in the context of cancer therapy and the associated search for antineoplastic drug candidates. I showcase a repeatable means for generating lists of potential targets which may be used in conjunction with methods like small molecule screening as part of a search for broadly effective antineoplastic agents. LÄS MER